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| Efficacy of Dahuang mudan decoction combined with leuprorelin for treating patients with uterine fibroids and its impacts on the serum matrix metalloproteinase-9 and cyclooxygenase-2 levels |
| Daxing District People's Hospital, Beijing, 102600 |
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Abstract To explore the efficacy of Dahuang mudan decoction combined with leuprorelin for treating patients with uterine fibroids, and to study its impacts on the serum matrix metalloproteinase-9 (MMP-9) and cyclooxygenase-2 (COX-2) levels of the patients. Methods: From April 2022 to November 2023, 106 patients with uterine fibroids were included and were randomly divided into two groups (53 cases in each group) by random number table method. The patients in the two groups were given treatment of leuprorelin for 3 months, and the patients in the study group received the Dahuang mudan decoction additionally. The changes of the traditional Chinese medicine syndrome scores, the uterine fibroids size, the uterine size, and the levels of estrogen, progesterone, MMP-9, COX-2 and vascular endothelial growth factor (VEGF) of the patients were compared between the two groups. The clinical efficacy and the drug safety of the patients in the two groups were assessed. Results: After treatment, the total effective rate (90.6%) of the patients in the study group was significantly higher than that (73.6%) of the patients in the control group. The scores of TCM syndromes (abdominal pain, increased menstrual volume, prolonged menstrual period, abnormal leucorrhea and dark complexion), the uterine fibroids volume, the uterine volume, and the levels of estrogen, progesterone and serum factors of the patients in the two groups after treatment were significantly lower than those before treatment, and the decreasing amplitude of which of the patients in the study group were significantly more than those of the patients in the control group. The levels of MMP-9 (1.06±0.35μg/ml) and COX-2 (0.19±0.06pg/L) of the patients in the study group were significantly lower than those (1.38±0.46μg/ml and 0.25±0.08pg/L) of the patients in the control group. The incidence of adverse reactions (3.8%) of the patients in the study group was significantly lower than that (15.1%) of the patients in the control group (all P<0.05). Conclusion: Dahuang mudan decoction combined with leuprorelin for treating the patients with uterine fibroids can effectively improve their total effective rate, decrease their traditional Chinese medicine syndrome scores, reduce their uterine fibroids volume and uterine volume, can effectively control the levels of estrogen and progesterone, can decrease their serum MMP-9, COX-2, and VEGF levels, and can reduce their side effect rate.
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