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| Influence of the intravenous anesthesia of propofol combined with sufentanil of patients with hysteroscopic surgery on their recovery quality and inflammatory response |
| The Third People's Hospital of Chengdu, Chengdu, Sichuan Province, 610031 |
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Abstract To investigate the clinical effect of the intravenous anesthesia of propofol combined with sufentanil of patients during hysteroscopic surgery. Methods: The clinical data of 125 patients with hysteroscopic surgery in the hospital from January 2023 to December 2023 were selected. These patients were divided into two groups according to the different anesthesia regimens. 65 patients in the control group were anesthetized with propofol combined with remifentanil, whereas 60 patients in the experimental group were anesthetized with propofol and sufentanil. The values of the intraoperative hemodynamic indexes, such as mean arterial pressure (MAP), heart rate (HR) and blood oxygen saturation (SpO2), the recovery quality, the inflammatory response and the adverse reactions of the patients were compared between groups. Results: There were no significant differences in the values of MAP, HR and SpO2 of the patients before anesthesia (T0) between the two groups (P>0.05). Compared with those of the patients in the two groups at T0, the values of MAP and HR at the time of cervical dilatation (T1), during the surgery (T2) and at the end of the surgery (T3) were significantly lower and the SpO2 value was significantly higher. The values of MAP, HR and SpO2 of the patients in the experimental group at T1, T2 and T3 were significantly higher than those of the patients in the control group (all P<0.05). The recovery time (10.54±1.27min) of the patients in the experimental group was significantly shorter than that (13.25±2.28min) of the patients in the control group. The score of vigilance and sedation scale (4.14±0.52 points) of the patients in the experimental group was significantly higher than that (3.74±0.43 points) of the patients in the control group, and the visual analogue scale score (2.53±0.65 points) of the patients in the experimental group at 1 hour after surgery was significantly lower than that (2.86±0.74 points) in the control group (P<0.05). The levels of C-reactive protein, tumor necrosis factor-α and interleukin-6 of the patients in the two groups after operation had increased significantly, and which (9.86±1.62 mg/ml, 39.81±12.29 pg/ml, and 45.71±15.28 pg/ml) of the patients in the experimental group were significantly lower than those (18.61±7.69 mg/ml, 75.53±25.69 pg/ml and 78.51±23.92 pg/ml) of the patients in the control group (all P<0.05). There was no significant difference in the incidence of the adverse reactions (29.2% vs. 23.3%) of the patients between the two groups (P>0.05). Conclusion: The intravenous anesthesia of propofol combined with sufentanil of the patients during hysteroscopic surgery has significant effect, which can reduce the intraoperative hemodynamic fluctuations, enhance the recovery quality and relieve the postoperative inflammatory response of the patients, and with the good safety.
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