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| Effects of Jin'gui wenjing decoction combined with the sequential estrogen and progesterone for treating patients with premature ovarian failure on their ovarian and inhibin B level |
| 1.Daxing District People's Hospital, Beijing, 102600; 2.Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing |
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Abstract To investigate the effects of Jin'gui wenjing decoction combined with the sequential estrogen and progesterone for treating patients with premature ovarian failure (POF) on their maximum plane mean of ovarian diameter (MOD) and inhibin B (INHB) level. Methods: A retrospective analysis was conducted on the clinical data of 97 patients with POF caused by kidney deficiency and blood stasis syndrome who had admitted to the hospital from March 2021 to February 2023. According to the different treatment methods, these patients were divided into control group (48 patients with the treatment of the sequential estrogen and progesterone) and study group (49 patients with the treatment of the combined Jin'gui wenjing decoction and the sequential estrogen and progesterone). The therapeutic effect, the score of kidney deficiency and blood stasis syndrome, the maximum plane of MOD, the ovarian blood flow status evaluated by the peak systolic velocity (PSV) and the resistance index (RI) of the ovarian artery, the levels of the serum sex hormones, such as follicle stimulating hormone (FSH) and estradiol (E2), and the INHB level of the patients were compared between two groups. Results: After 3 cycles of treatment, the total effective rate (93.9%) of the patients in the study group was significantly higher than that (79.2%) of the patients in the control group. The scores of kidney deficiency and blood stasis syndrome and the serum FSH level of the patients in the two groups had decreased significantly, and which (5.33±1.56 points and 36.98±5.17 U/L) of the patients in the study group were significantly lower than those (7.60±2.04 points and 43.45±7.68 U/L) of the patients in the control group. The ovarian maximum plane of MOD and the ovarian PSV value of the patients in the two groups had increased significantly, and which (23.54±6.38 mm and 18.52±4.26 cm/s) of the patients in the study group were significantly higher than those (19.73±4.26 mm and 15.49±3.37 cm/s) of the patients in the control group. The ovarian RI value of the patients in the two groups had decreased significantly, and which (0.58±0.15) of the patients in the study group was significantly lower than that (0.67±0.18) of the patients in the control group. The levels of serum E2 and INHB of the patients in the two groups had increased significantly, and which (38.42±7.89 ng/L and 64.85±7.64ng/L) of the patients in the study group were significantly higher than those (32.47±6.31 ng/L and 56.27±6.91 ng/L) of the patients in the control group (all P<0.05). Conclusion: Jin'gui wenjing decoction combined with the sequential estrogen and progesterone for treating patients with POF caused by kidney deficiency and blood stasis syndrome can increase their therapeutic effect, and which can improve the ovarian blood flow and diameter, increase the sex hormone and INHB levels, and alleviate related symptoms of the patients obviously.
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