To investigate the clinical efficacy of the perioperative comprehensive interventions as the antibiotic-free alternative during abortion of women, and to provide a safe, effective and antibiotic-free alternative for the perioperative management of the women with abortion. Methods: 240 women with two times of the abortion history who wanted abortion again were selected and were randomly divided into study group and control group from March 2020 to March 2022. The women in the observation group received comprehensive interventions during abortion, including the vaginal irrigation, the application of antimicrobial hydrogel on the vagina and cervix and the postoperative placement of a cervical antimicrobial membrane, while the women in the control group received the routine systemic antibiotic prophylaxis. The postoperative infection rate, the adverse reaction rate, the menstrual recovery, the endometrial thickness recovery, the intrauterine adhesion rate and the overall treatment effectiveness of the women were compared between the two groups. Results: There was no significant difference in the incidence of postoperative infection (1.7% vs. 3.3%) of the women between the two groups (P>0.05). The incidence of adverse reactions (1.7%) of the women in the observation group was significantly lower than that (7.5%) of the women in the control group. The recovery time of menstruation (32.9±6.3d) or the endometrial thickness (7.01±0.53 mm) of the women in the observation group was significantly better than that (55.4±9.1d or 5.72±0.51 mm) of the women in the control group. The incidence of intrauterine adhesion (1.7%) of the women in the observation group was significantly lower than that (9.2%) of the women in the control group. The total cost (5173±325 yuan) of the women in the observation group was significantly higher than that (4540±286 yuan) of the women in the control group (all P<0.05). Conclusion: The perioperative comprehensive interventions during the abortion of the women are safe and effective, can which accelerate the postoperative recovery and reduce the complications, and it is the antibiotic-free alternative and is worth to promoting.