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| Effect of colposcopy combined with human papillomavirus L1 capsid protein and p16 protein detections of women for screening their cervical intraepithelial neoplasia |
| West China Guang'an Hospital, Sichuan University, Guang'an, Sichuan Province, 638000 |
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Abstract To explore the clinical application effect of cervical lesion screening methods of colposcopy, human papillomavirus (HPV) L1 capsid protein detection and p16 protein detection of women for screening their cervical intraepithelial neoplasia (CIN). Methods: 201 women who received cervical cancer screening due to the suspected cervical lesions in gynecological clinic of the hospital were selected in this study from June 2022 to June 2023. The detections of HPV L1 capsid protein and p16 protein, and the colposcopy examination of these women were performed to diagnose their CIN. The effect of HPV L1 capsid protein detection, p16 protein detection, colposcopy and the combined of HPV L1 capsid protein and p16 protein detection, and colposcopy of the patients for diagnosing their CIN was analyzed based on the colposcopic cervical tissue biopsy as the diagnostic standard. Results: There were 121 women without cervical lesions, and 80 women with cervical lesions based on the colposcopic cervical tissue biopsy, including 54 cases with CINⅠ, 25 cases with CINⅡ and 1 case with CIN Ⅲ. The detection rate, the sensitivity, the specificity, and the accuracy of the colposcopy for screening CIN of the women were 53.7%, 81.3%, 64.5% and 71.1%, respectively, which of the HPV L1 capsid protein level for screening CIN were 55.2%, 73.8%, 57.0% and 63.7%, respectively, and which of the p16 protein level for screening CIN were 53.7%, 83.8%, 66.1% and 73.1%, respectively. The sensitivity, the specificity and the accuracy of the combined the colposcopic examination and the detections of the HPV L1 capsid protein and p16 protein levels of the women for screening their CIN were 97.5%, 57.9% and 74.6%, respectively. There was no significant difference in the sensitivity of the women for screening their CIN among the colposcopy, the HPV L1 capsid protein detection and p16 protein detection (χ2=2.667, P>0.05). The sensitivity of the combined colposcopy examination and the detections of the HPV L1 capsid protein and p16 protein of the women for screening their CIN was significantly higher than that of the colposcopy examination, the HPV L1 capsid protein detection or the p16 protein detection alone (χ2=11.123, 18.331, 8.901, P<0.05). There was no significant difference in the specificity for screening CIN of the women among the combined the colposcopy examination and the detections of the HPV L1 capsid protein and p16 protein, the colposcopy examination alone, the HPV L1 capsid protein detection alone and the p16 protein detection alone (χ2=3.233, P>0.05). Conclusion: The sensitivity of the colposcopic examination combined with the HPV L1 capsid protein and p16 protein detections of the women for screening their CIN increased significantly, which can provide valuable diagnostic evidence in clinic.
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