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| Serum interleukin-16, interleukin-10 and procalcitonin of neonates with pneumonia and their diagnostic values for differential the disease severity of pneumonia |
| Jiaozhou Center Hospital, Qingdao, Shandong Province, 266300 |
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Abstract To explore the changes of the serum interleukin-16 (IL-16), interleukin-10 (IL-10) and procalcitonin (PCT) of neonates with pneumonia, and to study the diagnostic values of the IL-16, IL-10 and PCT levels of the neonates for differential the disease severity of their pneumonia. Methods: The clinical data of 92 neonates with pneumonia admitted to hospital from February 2021 to June 2023 were collected retrospectively and these neonates were included in observation group. 90 healthy neonates born during the same period were included in control group. The serum levels of IL-16, IL-10 and PCT of the neonates were compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the values of serum IL-16, IL-10 and PCT levels of the neonates for diagnosing their pneumonia. According to the severity of the neonatal pneumonia in the observation group, the neonates were divided into group A (61 neonates without severe pneumonia) and group B (31 neonates with severe pneumonia). The serum levels of IL-16, IL-10 and PCT of the neonates were compared between group A and group B. ROC curve was used to analyze the values of serum IL-16, IL-10 and PCT levels of the neonates for diagnosing their severity of pneumonia. Results: The serum levels of IL-16 (336.82±100.51 ng/L), IL-10 (12.74±3.71 ng/L) and PCT (6.34±2.18μg/L) of the neonates in the observation group were significantly higher than those (123.65±29.74 ng/L, 8.94±1.87 ng/L and 3.51±1.33μg/L) of the neonates in the control group. ROC curve analysis showed that the area under the curve (AUC) of the serum IL-16 level, the IL-10 level and the PCT level of the neonates for diagnosing their pneumonia were 0.984, 0.815 and 0.873, respectively (all P<0.05). The serum levels of IL-16, IL-10 and PCT of the neonates in group A were significantly higher than those of the neonates in group B. ROC curve analysis showed that the AUC of serum IL-16, IL-10 and PCT of the neonates for diagnosing their severity of pneumonia were 0.964, 0.757 and 0.866, respectively (all P<0.05). Conclusion: The serum levels of IL-16, IL-10 and PCT of the neonates can effectively diagnose their pneumonia, and which have certain application value in evaluating the severity of the neonatal pneumonia.
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