To observe the clinical application effect of the different volumes of ropivacaine used in the transversus abdominis plane block (TAPB) by the ultrasonic guidance combined with general anesthesia for patients during laparoscopic surgery of benign ovarian tumors. Methods: 90 patients with benign ovarian tumors were enrolled and were randomized divided into two groups by simple randomization method using a random number table from June 2021 to May 2023. The patients in both groups received ropivacaine used in TAPB combined with general anesthesia regimen. The patients in group A were given 25ml of 0.33% ropivacaine for bilateral transversus abdominis plane block under ultrasound guidance and the patients in group B were given 25ml of 0.33% ropivacaine for bilateral transversus abdominis plane block under ultrasound guidance, and then the patients were performed general anesthesia after anesthesia onset. The onset time of nerve block anesthesia, the values of intraoperative heart rate (HR) and mean arterial pressure (MAP), the postoperative pain status and the anesthesia-related complications of the patients in both groups were observed. Results: The onset time of the nerve block anesthesia (4.21±0.48 min) and the time from anesthesia to operation (12.38±2.19 min) of the patients in group A were significantly shorter than those (4.58±0.64 min and 13.97±2.35min) of the patients in group B. The values of HR and MAP of the patients in group A at different time points were significantly higher than those of the patients in group B. The visual analogue scale (VAS) score (3.96±0.35 points) of the patients in group A at 6 hours after operation was significantly lower than that (4.12±0.40
points) of the patients group B (all P<0.05). There was no significant difference in the incidence of the postoperative anesthesia-related complications (13.3% vs. 8.9%) of the patients between the two groups (P>0.05). Conclusion: The high volume of ropivacaine used in TAPB combined with general anesthesia for the patients during laparoscopic surgery of benign ovarian tumors has less influence on their HR and MAP, and the patients has better postoperative recovery comfort, without increase of the anesthesia-related complications of the patients.