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| Research progress of the ovarian follicle development associated signaling pathways |
| The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Jiangsu Maternal and Child Health Care Hospital, Nanjing, Jiangsu Province, 210029 |
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Abstract Follicle is the basic functional unit of the ovum production and sex hormone secretion. The development of the follicle is a continuous and dynamic process, involving lots of signaling pathways and the regulating effect by hormones. The development of the follicle is closely related to the female reproductive health, however, the current researches on follicles are still limited to the single target-single pathway, and the systematic molecular network mechanism is lack. Plenty of studies have shown that the biological processes of the signaling pathways involved in the regulation of follicle development mainly include oocyte meiosis, primordial follicle activation, granulosa cell proliferation, and sex hormone synthesis and secretion. Therefore, this paper reviews the follicle development related signaling pathways and their mechanism of action, aiming to provide theoretical basis and idea for the follow-up basic research and clinical treatment of the follicular dysplasia related diseases.
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