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| Clinical value of the multimodal ultrasound for monitoring endometrial receptivity of patients during perioperative period to evaluate their full-term birth after frozen-thawed embryo transfer |
| 1.Graduate School of Zhejiang University of Traditional Chinese Medicine Zhejiang, Hangzhou, Zhejiang Province, 310053；2.Lishui People's Hospital, Zhejiang Province |
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Abstract To analyze the clinical effect of the multimodal ultrasound for monitoring endometrial parameters of patients during perioperative period to evaluate the fullterm birth after frozen-thawed embryo transfer. Methods: The clinical data of 248 childbearing age patients with 437 freeze-thaw embryo transplatation cycles from May 2019 to July 2022 were collected retrospectively. The transvaginal multimodal ultrasound technology was used to monitoring the endometrum of these patients. The endometrial score of these patients were given by transvaginal multimodal ultrasound, and based on the score, these patients were divided group A (patients with 86 cycles and <12 points) and group B (patients with 351 cycles and ≥12 points). The baseline data, the freeze-thaw embryo data, the score by transvaginal multimodal ultrasound, the clinical pregnancy outcomes, and the other indicators of the patients in the two groups were analyzed. The influencing factors of full-term birth of the patients after frozen-thawed embryo transfer were also analyzed. Results: The clinical pregnancy rate (47.7%), the live birth rate (39.5%), the premature birth rate (34.2%), and the full-term birth rate (48.8%) of the patients in group A were significantly lower than those (59.0%, 51.6%, 13.0%, and 74.4%) of the patients in group B. The rates of early pregnancy loss, late pregnancy loss, and ectopic pregnancy of the patients in group A were significantly higher than those of the patients in group B (all P<0.05). Pearson univariate analysis showed that the endometrial score by multimodal ultrasound, the cause of infertility, and the twin pregnancy or not of the patient with freeze-thaw embryo transplantation were the influence factors of their full-term birth. Multivariate logistic regression analysis showed that the endometrial score < 12 points by multimodal ultrasound, the secondary infertility, and the twin pregnancy of the patient were the independent influencing factors of their full-term birth after embryo transfer (all P<0.05). Conclusion: Transvaginal multimodal ultrasound can accurately and noninvasively assess the endometrial receptivity of the patients during the window of the pregnancy after frozen-thaw embryo transfer, which provides an early intervention for improving the full-term birth of the patients after embryo transfer.
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