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| Predictive value of uterine artery pulsation/resistance index combined with the anti mullerian hormone level of women for their pregnancy outcomes after assisted reproduction of IVF-ET |
| 1. Shenzhen Hengsheng Hospital Affiliated to Southern Medical University, Shenzhen, Guangdong Province, 518000；2. Dongzhou Community Health Service Center of Shenzhen Guangming, the University of Chinese Academy of Sciences |
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Abstract To explore the predictive value of uterine artery pulsation (UtA-PI) and uterine artery resistance index (UtA-RI) combined with the anti mullerian hormone (AMH) level of women for their pregnancy outcomes after assisted reproduction of in vitro fertilization embryo transfer (IVF-ET). Methods: The clinical data of 165 women with assisted reproduction of IVF-ET from February 2020 to February 2022 were selected in this study. These women were divided into group A (95 women with clinical pregnancy) and group B (70 women without clinical pregnancy) according to the results of IVF-ET. The values of UtA-PI and UtA-RI, the serum AMH level, and the general clinical data of the women were analyzed and were compared between the two groups. Receiver operating characteristic (ROC) curve was drawn to analyze the predictive values of UtA-PI and UtA-RI, and the AMH level of the women for their pregnancy outcomes after IVF-ET. Multifactor logistic regression analysis was used to analyze the influencing factors of the pregnancy outcomes of the women after assisted reproduction. Results: The values of UtA-PI and UtA-RI of the women in group B were significantly higher than those of the women in group A, and the serum AMH level of the women in group B was significantly lower than that of the women in group A (all P<0.05). ROC curve analysis showed that the area under the curve, the cutoff value, the sensitivity, and the specificity of the serum AMH level of the women for predicting their pregnancy outcomes after IVF-ET were 0.855, 5.21ng/ml, 91.4%, and 68.4%, respectively. The area under the curve, the cutoff value, the sensitivity, and the specificity of the UtA-PI value of the women for predicting their pregnancy outcomes after IVF-ET were 0.795, 1.66, 91.4%, and 55.8%, respectively. The area under the curve, the cutoff value, the sensitivity, and the specificity of the UtA-RI value of the women for predicting their pregnancy outcomes after IVF-ET were 0.832, 0.94, 91.4%, and 62.1%, respectively. The area under the curve, the sensitivity, and the specificity of the combined serum AMH level and UtA-PI and UtA-RI values of the women for predicting their pregnancy outcomes after IVF-ET were 0.922, 85.7%, and 86.3%, respectively. Multivariate logistic regression analysis showed that the serum AMH level, the values of UtA-PI and UtA-RI, and the number of embryos transfer of the women were the influencing factors of their pregnancy outcomes after IVF-ET (P<0.05). Conclusion: The values of UtA-PI and UtA-RI, and the AMH level of the women are closely related to their pregnancy outcomes after IVF-ET, and which of the women all have good predictive efficacy for their pregnancy outcomes after IVF-ET. The combined serum AMH level and UtA-PI and UtA-RI values of the women for predicting their pregnancy outcomes after IVF-ET has the best value.
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