|
|
|
| Th1/Th2 balance and cytokines expressions levels in fallopian tube fluid of patients with tubal obstructive infertility and their clinical significance |
| Qiqihar Hospital of Traditional Chinese Medicine, Qiqihar, Heilongjiang Province, 161000 |
|
|
|
|
Abstract To explore the correlation between the Th1/Th2 balance and the cytokines expressions in fallopian tube fluid of patients with tubal obstructive infertility and their clinical significance. Methods: 54 patients with tubal obstructive infertility who had undergone fallopian tube recanalization were selected in study group between September 2020 and September 2021, and 32 women who had undergone tubal ligation during the same period were enrolled in control group. The blood samples were collected before surgery and the fallopian tube fluid samples were collected during surgery. The levels of Th1 cytokine γ-interferon (IFN-γ), interleukin (IL)-2, and Th2 cytokines, such as IL-4 and IL-6, of the women in the two groups were detected by enzyme-linked immunosorbent assay, and the differences of which of the women were compared between of the women. The FN-γ/IL-4 balance of the women was calculated. Results: The levels of IFN-γ, IL-2, IL-4, and IL-6 in serum and in tubal fluid of the women in the study group were significantly higher than those of the women in the control group, and the Th1/Th2 in serum and in tubal fluid of the women in the study group were significantly lower than those of the women in the control group (P<0.05). Logistics regression analysis showed that the pelvic inflammatory disease and the decreased Th1/Th2 in peripheral blood and in tubal fluid of the women were the risk factors of their tubal obstructive infertility (P<0.05). Conclusion: Th1 cytokines and Th2 cytokines in serum and in fallopian tube fluid of the women with tubal obstructive infertility are highly expressed. The balance of Th1/Th2 shifts to Th2, and the imbalance of Th1/Th2 cytokines of the women are the risk factors of their tubal obstructive infertility.
|
|
|
|
|
|
|
|
|
