|
|
|
| Efficacy of the endometrial receptivity improvement of Zishen yutai pill for treating patients with recurrent abortion caused by luteal insufficiency |
| 1.Hainan Western Central Hospital, Danzhou, Hainan Province, 571799；2.Sanya People's Hospital of Hainan Province |
|
|
|
|
Abstract To evaluate the effects of Zishen yutai pill for treating patients with recurrent abortion caused by luteal insufficiency on their endometrial receptivity. Methods: 156 patients with recurrent abortion caused by luteal insufficiency between June 2019 and March 2021 were enrolled as the study subjects, and they were divided into three groups (52 cases in each group) by using simple randomization method. The patients in group A were treated with dydrogesterone tablets combined with Zishen yutai pill, the patients in group B were treated with Zishen yutai pill, and the patients in group C were treated with dydrogesterone tablets. Multimodal ultrasound was used to evaluate the differences of the endometrial receptivity, such as endometrial thickness, endometrial volume (EV), and vascular flow index (VFI) of the patients in the three groups. The differences of the endometrial morphology of the patients in the three groups were explored before and after treatment. The differences of the pregnancy outcomes and the occurrence of adverse reactions of the patients during treatment in the three groups were analyzed. Results: The values of endometrial thickness, EV, and VFI of the patients in the three groups after treatment had increased significantly, and which of the patients in group A was significantly higher than that of the patients in group B and that of the patients in group C (P<0.05), but which of the patients had no significant difference between group B and group C (P＞0.05). The endometrial morphology of the patients in the three groups after treatment had changed significantly, which of the patients in group A was significantly better than that of the patients in group B and in group C (P<0.05), but which of the patients had no significant difference between group B and group C (P＞0.05). The clinical pregnancy rate (59.6%) of the patients in group A was significantly higher than that (32.7%) of the patients in group B and that (38.4%) of the patients in group C (P<0.05), but which of the patients had no significant difference between group B and group C (P＞0.05). There were no significant differences in the rates of abortion again, preterm birth, and adverse reactions during treatment of the patients among the three groups (P＞0.05). Conclusion: Zishen yutai pill combined with dydrogesterone tablets for treating the patients with recurrent abortion caused by luteal insufficiency has better efficacy on the endometrial receptivity of the patients, and which can increase the clinical pregnancy.
|
|
|
|
|
|
|
|
|
