To explore the clinical value of umbilical artery ultrasound parameters values combined with modified biophysical phase score (MBPS) of pregnant women with preeclampsia during the third trimester of pregnancy for predicting the adverse outcomes of their perinatal infants. Methods: A total of 110 pregnant women with single-fetus and preeclampsia who had delivered in hospital from March 2017 to March 2021 were collected in study group retrospectively, and another 110 healthy pregnant women with single-fetus who had accepted regularly examined and delivered in hospital during the same period were collected in control group retrospectively. Color Doppler ultrasound of umbilical artery before delivery was performed in the women in both groups, and the MBPS scores of the women in both groups were obtained. Receiver operator characteristic (ROC) curve was used to analyze the value of the umbilical artery ultrasound parameters values combined with MBPS scores of the women with preeclampsia for predicting the outcomes of their perinatal infants. Results: The incidences of perinatal preterm birth, neonatal asphyxia, low birth weight, and fetal distress of the women in the study group were significantly higher than those of the women in the control group. The values of umbilical artery ultrasound S/D (3.89±0.75, 2.12±0.59), PI (1.30±0.29, 0.88±0.15), and RI (0.79±0.12, 0.55±0.08) of the women in the study group were significantly higher than those of the women in the control group. The abnormal rate of MBPS score (49.1%) of the women in the study group was significantly higher than that (17.3%) of the women in the control group (all P＜0.05). ROC curve showed that, when the cutoff values were 3.12, 1.09, and 0.68, the values of the area under the curve (AUC) of S/D, PI, and RI in the umbilical artery ultrasound parameters of the women with preeclampsia for predicting their adverse perinatal infants outcomes were 0.785, 0.792, and 0.801, respectively, the sensitivity of which were 82.6%, 84.1%, and 85.7%, respectively, and the specificity of which were 71.9%, 72. 1%, and 75.3%, respectively. The AUC, the sensitivity, and the specificity of MBPS score of the women with preeclampsia for predicting their adverse perinatal infants’ outcomes were 0.744, 72.2%, and 60.3%, respectively. The AUC, the sensitivity, and the specificity of combined values of the umbilical artery ultrasound parameters of the women with preeclampsia for predicting their adverse perinatal infants’ outcomes were 0.919, 94.3%, and 96.2%, respectively. Conclusions: The umbilical artery ultrasound and MBPS score of the women with preeclampsia during the third trimester of pregnancy for predicting their adverse perinatal infant s’ outcomes have some prediction values. The combination of the umbilical artery ultrasound parameters and the MBPS score can significantly improve the predictive sensitivity and specificity, and which is of great significance to guide the evaluation and the intervention in clinical.