To analyze the correlation between the squamous cell carcinoma antigen (SCC), and the levels of serum ferritin (SF), carbohydrate antigen 72-4 (CA72-4), and carbohydrate antigen 15-3 (CA15-3) of women and their cervical squamous carcinoma occurrence. Methods: A total of 60 women with cervical squamous cell carcinoma were selected in study group and another 60 healthy women who received physical examination were selected in control group from January 2019 to August 2021. The levels of SCC, SF, CA72-4, and CA15-3 of the women in the two groups were detected by automatic electrochemiluminescence immunoassay, and which of the women were compared between the two groups, and among the women with different differentiation /stage /prognosis of their cervical squamous carcinoma. Results: The levels of SCC (4.21±1.05 ng/L), SF (272.63±29.58 ng/ml), CA72-4 (19.88±3.71 U/ml), and CA15-3 (215.46±36.89 U/ml) of the women in the study group were significantly higher than those (0.50±0.12ng/L, 59.15±7.11 ng/ml, 1.49±0.85 U/ml, and 8.37±0.51 U/ml) of the women in the control group. In the study group, the levels of SCC, SF, CA72-4, and CA15-3 of the women with low-differentiated cervical squamous cell carcinoma were significantly higher than those of the women with high-differentiated cervical squamous cell carcinoma, and which of the women had increased significantly with their higher clinical stage of cervical squamous cell carcinoma increase. The levels of SCC, SF, CA72-4, and CA15-3 of the women with tumor progression were significantly higher than those of the women without tumor progression (all P＜0.05). Conclusions: The levels of SCC, SF, CA72-4, and CA15-3 of the women with cervical squamous cell carcinoma increase abnormally, and are correlation with the degree of differentiation or the staging of the carcinoma of the women, so which can be used as the auxiliary indicators of the follow-up and the prognosis evaluation of the women with cervical squamous cell carcinoma.