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| Correlation between the thyroid hormones levels of pregnant women with preeclampsia and their severity of preeclampsia |
| 1.903 Hospital, Jiangyou, Sichuan Province, 621700；2. Zigong Maternal and Child Health Care Hospital, Zigong, Sichuan Provinc |
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Abstract To analyze the correlation between the thyroid hormones levels of pregnant women with preeclampsia (PE) and their PE severity. Methods: A total of 126 pregnant women with PE selected in observation group and 60 healthy pregnant women with the same gestational weeks were selected in control group from February 2019 to March 2022. The levels of thyroid function indicators, such as thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), and the values of liver-kidney function indicators, such as aspartate aminotransferase (AST) and urinary albumin/creatinine ratio (uACR) of the women were compared between the observation group and the control group, and among the women with different severities of PE in the observation group. The thyroid dysfunction of the women with different severities of PE in the observation group was counted. Pearson correlation coefficient was used to analyze the correlation between the thyroid function indicators of the women with PE and their liver-kidney function indicators. The pregnancy outcomes and neonatal condition of the women in the observation group were followed up. Results: In the observation group, there were 50 women with severe PE in group A and 76 women with mild PE in group B. The levels of the serum TSH and AST, and the uACR value of the women in group A, in group B, and in control group had decreased gradually, while the levels of FT3 and FT4 of the women had increased gradually (all P＜0.05). The incidence of hypothyroidism (16.0%) and the subclinical hypothyroidism (12.0%) of the women in group A were significantly higher than those (4.0% and 2.6%) of the women in group B (P＜0.05), but there was no significant difference in the incidence of simple TPOAb positive (10.0% vs. 4.0%) of the women between the two groups (P＞0.05). The uACR value and AST level of the women in group B had no correlated with their TSH, FT3, and FT4 levels (>0.05). In group A, the AST level of the women was positively correlated with their TSH level, and the uACR value of the women was positively correlated with their TSH level and was negatively correlated with their FT3 level (P＜0.05). The incidences of preterm birth, fetal growth restriction, fetal distress, and amniotic fluid contamination of the women in group A were significantly higher than those of the women in group B (P＜0.05), but there were no significant differences in the incidences of placental abruption, HELLP syndrome, cardiac insufficiency, and fetal death of the women between the two groups (P＞0.05). Conclusion: The PE progression of the pregnant women is closely related to their hypothyroidism, and it is recommended that the detections of the relevant indicators of these women should be strengthened so as to grasp the dynamics of their PE and to provide the evidences for timely adjusting the treatment regimen.
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