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| Correlation between the D-dimer/fibrinogen ratio of obese women during the first trimester of pregnancy and their occurrences of preeclampsia and adverse perinatal outcomes |
1.Dingzhou People’s Hospital, Hebei Province, 073000；2. The First Hospital of Handan, Hebei Province；
3. Guangyang District Maternal and Child Health Care Hospital, Langfang, Hebei Province |
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Abstract To explore the correlation between the D-dimer/fibrinogen (D/F) ratio of obese pregnant women during the first trimester of pregnancy and their occurrences of preeclampsia and adverse perinatal outcomes. Methods: A total of 168 obese pregnant women were selected in observation group, and 100 pregnant women with normal weight who came to antenatal examination were selected in control group from January 2021 to January 2022. The serum D-dimer (D-D) and fibrinogen (FIB) levels of the women in the two groups were detected, and the D/F ratio of the women in the two groups was calculated. The optimal cut-off value of the D/F ratio of the women for predicting their occurrences of preeclampsia and adverse perinatal outcomes was determined by receiver operating characteristic (ROC) curve. According to the cut-off value, the women in the observation group were divided group A (women with high D/F ratio) and group B (women with low D/F ratio). The occurrences of preeclampsia and adverse perinatal outcomes of the women in group A and group B were analyzed. Results: The levels of serum D-D (4.58±1.25mg/L) and FIB (3.28±0.97g/L), and the D/F ratio (1.40±0.36) of the women in the observation group during the first trimester of pregnancy were significantly higher than those (2.20±0.58mg/L, 2.59±0.56g/L, and 0.85±0.11) of the women in the control group (all P＜0.05). ROC analysis showed that the optimal cut-off value of D/F was 0.95, and there were 73 women with D/F ratio >0.95 in group A and 95 women with D/F ratio ≤0.95 in group B. The incidence of preeclampsia (17.8%) of the women in group A was significantly higher than that (2.1%) of the women in group B, and the incidences of premature birth (13.7%), fetal distress (20.6%), and neonatal asphyxia (4.0%) of the women in group A were significantly higher than those (2.1%, 5.3%, and 0) of the women in group B (all P＜0.05). Conclusion: The incidences of preeclampsia and adverse perinatal outcomes of the obesity pregnant women with high D/F ratio during the first trimester of pregnancy are higher.
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