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| Anesthetic and analgesic effect of nalbuphine combined with propofol during hysteroscopic induced abortion |
| 1.Lin'an District Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Provinve, 311300；2.Zhejiang Hospital of Traditional Chinese Medicine (The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine), Hangzhou, Zhejiang Province |
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Abstract To explore the anesthetic and analgesic effect of nalbuphine combined with propofol during hysteroscopic induced abortion of women. Methods: Totally 120 women who wanted hysteroscopic induced abortion were selected and were divided into two groups (60 cases in each group) according to the random number table method from August 2022 to September 2022. The women in the control group were given propofol for anesthesia and the women in the observation group were given nalbuphine combined with propofol for anesthesia. The values of vital signs, such as mean arterial pressure (MAP), heart rate (HR), and blood oxygen saturation (SpO2), the analgesic effect, the dosage propofol used, the postoperative recovery situation, the levels of serum inflammatory factors, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and the occurrence of adverse reactions of the women were compared between the two groups. Results: The values of intraoperative MAP and HR of the women in both groups had decreased firstly and then had increased, and which of the women in the observation group at intraoperative 5 min was significantly higher than that of the women in the control group (P＜0.05). There was no significant differences in the SpO2 vale of the women between the two groups, among the women with different intraoperative time, and between the interactions (P＞0.05). The dosage of propofol used (101.83±18.66 mg), the recovery time of consciousness (4.67±1.28 min), and the recovery time of orientation (7.03±1.62 min) of the women in the observation group were significantly lower than those (133.87±29.47 mg, 6.07±1.54 min, and 8.92±1.88 min) of the women in the control group. The VAS scores of the women in both groups had increased firstly, and then had decreased, but which (1.98±0.47 points, 3.03±0.52 points, and 2.60±0.41 points) of the women in the observation group at the recovery of consciousness, 30 min after recovery of consciousness, and in 1 h after recovery of consciousness were significantly lower than those (2.22±0.59 points, 3.47±0.43 points, and 2.78±0.57 points) of the women in the control group. The levels of TNF-α (21.40±5.19 ng/L) and IL-6 (18.46±3.65 ng/L) of the women in the observation group were significantly lower than those (24.08±5.98 ng/L and 20.95±4.92 ng/L) of the women in the control group. The total incidence of adverse reactions (10.0%) of the women in the observation group was significantly lower than that (26.7%) of the women in the control group (all P＜0.05). Conclusion: Nalbuphine combined with propofol used during hysteroscopic induced abortion of the women has good anesthetic and analgesic effect, and which can reduce the dosage of propofol used and relieve the postoperative inflammatory response of the women, with higher safety.
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