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| Impacts of the intravenous anesthesia by esketamine combined with propofol during hysteroscopic surgery of patients on their intraoperative physical signs and recovery quality |
| Taihe County People's Hospital, Anhui Province, 236600 |
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Abstract To investigate the impacts of the intravenous general anesthesia by esketamine combined with propofol during hysteroscopic surgery of patients on their intraoperative physical signs and recovery quality. Methods: 80 patients who were scheduled to undergo hysteroscopic surgery were selected as research subjects and randomly divided into two groups (40 cases in each group) from March to October 2022. The patients in the study group had received intravenous general anesthesia by esketamine combined with propofol regimen, while the patients in the control group had received intravenous general anesthesia by sufentanil combined with propofol. The preoperative and postoperative pain scores, the values of intraoperative physical signs, such as arterial oxygen saturation (SpO2), respiratory rate (RR), heart rate (HR), and mean arterial pressure (MAP), the onset time of anesthesia, the postoperative awakening time, the satisfaction, the recovery quality, and the postoperative adverse reactions rate of the patients were compared between the two groups. Results: The anesthetic onset time (32.0±5.3s) and the postoperative awakening time (2.6±0.9min) of the patients in the study group were significantly shorter than those (41.7±8.3s and 4.2±1.0min) of the patients in the control group, and the dosage of propofol used (1.9±0.3 mg/kg) of the patients in the study group was significantly less than that (2.4±0.4 mg/kg) of the patients in the control group. The VAS scores at 10 min (3.83±0.68 points) and in 30 min after operation (3.27±0.59 points) of the patients in the study group were significantly lower than those (4.72±0.67 points and 4.26±0.66 points) of the patients in the control group (P＜0.05). The VAS score in postoperative 24 h (1.46±0.22 points) and the postoperative satisfaction rate (92.5%) of the patients in the study group had no significantly different from those (1.49±0.25 points and 82.5%) of the patients in the control group (P＞0.05). There were no significant differences in the values of SpO2, RR, HR, and MAP of the patients before anesthesia between the two groups (P＞0.05). From the absence of eyelash response to the recovery of consciousness, the SpO2 and RR values of the patients in the control group were significantly lower than those before anesthesia, but which of the patients in the study group were significantly better than those of the patients in the control group. The HR value of the patients in both groups from the cervical dilation to 5 min after the start of surgery was significantly higher than that before anesthesia, and the MAP value of the patients in both groups from 5 min after the start of surgery to the consciousness recovery was significantly higher than that before anesthesia (P＜0.05). The Steward recovery scores at 5 min after entering the postanesthesia care unit (PACU) (3.61±0.70 points) and after leaving PACU (5.58±0.46 points) of the patients in the study group were significantly higher than those (3.26±0.62 points and 5.12±0.53 points) of the patients in the control group. The Ricker sedation-agitation score (5.36±0.65 points) of the patients in the study group was significantly lower than that (5.83±0.71 points) of the patients in the control group (P＜0.05). There was no significant difference in the total adverse reactions rate (5.0% vs.20.0%) of the patients between the two groups (P＞0.05). Conclusion: Esketamine combined with propofol for intravenous general anesthesia during hysteroscopic surgery of the patients can increase the analgesic effect, and without increase of the adverse reactions.
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