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| Correlation between the serum soluble CD14 and toll-like receptor 2 levels of pregnant women with gestational diabetes mellitus and their islet cell function and pregnancy outcomes |
| Nanyang Second People's Hospital, Nanyang, Henan Province, 473000 |
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Abstract To explore the correlation between the serum soluble CD14 (sCD14) and toll-like receptor 2 (TLR2) levels of pregnant women with gestational diabetes mellitus (GDM) and their islet cell function and pregnancy outcomes. Methods: A total of 113 pregnant women with GDM from January 2020 to June 2022 were selected in study group retrospectively, and 96 normal pregnant women admitted for physical examination during the same period were selected in control group. The levels of serum sCD14, TLR2, fasting insulin (FINS) and fasting blood glucose (FPG) of the women in the two groups were detected, and the values of insulin resistance index (HOMA-IR) and islet beta cell function index (HOMA-β) of the women in the two groups were calculated. The levels of serum sCD14 and TLR2, the values of HOMA-IR and HOMA-β, and the pregnancy outcomes of the women were analyzed and compared between the two groups. Pearson correlation was used to analyze the correlation between the serum sCD14 and TLR2 levels of the women with GDM and their islet cell function. Multivariate logistic regression was used to analyze the influencing factors of the pregnancy outcomes of the women with GDM. Results: The levels of serum sCD14, TLR2, FPG, and FINS, and the HOMA-IR value of the women in the study group were significantly higher than those of the women in the control group, but the HOMA-β value of the women in the study group was significantly lower (P＜0.05). Pearson correlation analysis showed that the serum sCD14 level of the women with GDM was positively correlated with their HOMA-IR value, and was negatively correlated with their HOMA-βvalue. The serum TLR2 level of the women with GDM was positively correlated with their HOMA-IR value, and was negatively correlated with their HOMA-β value (all P＜0.05). The overall incidence of adverse pregnancy outcomes (38.9%) of the women in the study group was significantly higher than that (16.7%) of the women in the control group (P＜0.05). The levels of serum sCD14 and TLR2 of the women with poor pregnancy outcomes in the study group were significantly higher than those of the women with normal pregnancy outcomes (P＜0.05). Multivariate logistic regression analysis showed that the age ≥30 years old, the pre-pregnancy body mass index >28kg/m2, the adverse pregnancy history, the poor blood glucose control, and the levels of serum sCD14 ≥310.44ng/ml and TLR2 ≥17.14g/L of the women with GDM were all the risk factors of their adverse pregnancy outcomes (P＜0.05). Conclusion: The levels of serum sCD14 and TLR2 of the women with GDM are increased abnormally, and both of which are closely related to the function of islet cells and the adverse pregnancy outcomes of these women.
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