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| Effects of the less oocytes number of women on their blastocyst biopsy in preimplantation genetic testing cycle |
| The Fourth Hospital of Shijiazhuang; Gynecology and Obstetrics Hospital Affiliated to Hebei Medical University, Hebei Provincial Key Laboratory of MaternalFetal Medicine, Shijiazhuang, Hebei Province, 050011 |
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Abstract To investigate the effects of the number of oocytes retrieved of women on their blastocyst biopsy in preimplantation genetic testing (PGT) cycle. Methods: The women with the number of oocytes retrieved≤8 oocytes who wanted PGT cycle were divided in group A (women with 1-3 oocytes), group B (women with 4-6 oocytes), and group C (women with 7-8 oocytes). The proportions of the PGT of aneuploidy (PGT A) and the blastocyst biopsy in each oocytes retrieved cycle, and the egg utilization rate of the women were compared among group A, group B, and group C. Results: A total of 168 PGT cycles were included in this study, of which, the PGT A cycles counted 53.6% (90/168), and the biopsy cycles counted 72.4% (118/163). There were 49 women in group A, 70 women in group B, and 49 women in group C. The proportions of the women with PGT A cycles in group A, in group B, and in group C were 65.3%, 57.1%, and 36.7%, respectively, and which had significant differences among the three groups. The proportions of the women with biopsy cycles in group A, in group B, and in group C were 38.6%, 74.3%, and 100%, respectively, and which had significant differences among the three groups. The egg utilization rates of the women in group A, in group B, and in group C were 24.2%, 28.7%, and 44.4%, respectively, and which had significant differences among the three groups. The rates of high-quality blastocysts of the women in group A, in group B, and in group C were 8.8%, 12.6%, and 14.9%, respectively,and which had significant differences among the three groups (P<0.05). Conclusion: When the number of oocytes retrieved ≤6 oocytes, especially ≤3 oocytes, PGT A should be performed cautiously. When the number of oocytes ≥7 oocytes, the success rate of blastocyst biopsy in PGT cycles is higher.
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