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| Analgesic and sedation effect of dexmedetomidine intrathecal combined with ropivacaine for patients during hysteroscopic surger |
| 1. The Eighth People's Hospital of Hefei, Hefei, Anhui Province, 238000；2. Chaohu Hospital of Anhui Medical University |
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Abstract To compare the analgesic effect and adverse reactions of ropivacaine combined with dexmedetomidine or fentanyl during hysteroscopic surgery. Methods: A retrospective analysis was performed on 92 patients who underwent gynecological hysteroscopy elective surgery between September 2019 and April 2022. According to the different anesthesia drugs used, these patients were divided into group A (30 patients with 7.5 mg ropivacaine administered in subarachnoid space), group B (30 patients with 7.5 mg ropivacaine combined with 5μg dexmedetomidine in subarachnoid space), and group C (32 patients with 7.5 mg ropivacaine combined with15 μg fentanyl in subarachnoid space). The onset time of sensory and motor block, the maintain time of sensory and motor block, the postoperative pain score, the sedation score, and the adverse reactions situation of the patients were recorded. Results: There were no significant differences in the onset time of sensory and motor block of the patients between group B and group C, but which of the patients in group B and group C were significantly shorter than those of the patients in group A. The duration of sensory block (191.25±35.28min) of the patients in group B was significantly longer than that (149.86±33.97min) of the patients in group C and that (139.44±25.21min) of the patients in group A (P<0.05). There was no significant difference in the motor block duration of the patients among the three groups (P>0.05). The Ramsay sedation score of the patients in group B was significantly higher than that of the patients in group A and that of the patients in group C (all P<0.05). The VAS score of the patients in group B in postoperative 6h and 12h (0.31±0.14 and 2.05±0.87) were significantly lower than those (1.35±0.52 and 4.25±1.22) of the patients in group A and those (0.79±0.33 and 3.11±1.04) of the patients in group C (P<0.05). There were 2 (6.3%) patients with bradycardia occurred in group C, and the overall incidence of adverse reactions (46.9%) of the patients in group C was significantly higher than that (13.3%) of the patients in group A and that (16.7%) of the patients in group B (P<0.05). Conclusion: Compared with those of fentanyl, dexmedetomidine combined with ropivacaine used in hysteroscopic surgery has better sedative and analgesic effect, and with less adverse reactions and higher safety.
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