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| Clinical value of p16/Ki67 double staining detection for predicting the prognosis outcomes of the cervical atypical squamous hyperplasia |
| Shanxi Provincial Maternal and Child Health Care Hospital, Taiyuan, Shanxi Province, 030000 |
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Abstract To study the value of p16/Ki67 double staining detection for predicting the prognosis outcomes of the cervical atypical squamous hyperplasia. Methods: The clinical data of 610 patients who had been diagnosed with atypical squamous hyperplasia from July 2019 to June 2020 were selected in this study. After 1 year of follow up, these patients were divided into group A (patients with progressive cervical atypical squamous hyperplasia), group B (patients with continuous cervical atypical squamous hyperplasia), and group C (patients with regression of cervical atypical squamous hyperplasia) according to the prognosis outcomes of the cervical atypical squamous hyperplasia. The general data, and the results of TCT and p16/Ki67 double staining detection of the patients in the three groups were analyzed. The value of the result of p16/Ki67 double staining detection for predicting their cervical atypical squamous hyperplasia was analyzed. Based on the p16/Ki67 double staining detection result, these patients were divided into group 1 (patients with positive result) and group 2 (patients with negative result). The correlation between the results of p16/Ki67 double staining detection of the patients after 1 year of follow up and their prognosis outcomes of the cervical atypical squamous hyperplasia was analyzed. Results: After 1 year of follow-up, among 610 patients, 150 (24.6%) patients were in group C, 342 (56.1%) patients were in group B, and 118 (19.3%) patients were in group A. The positive rate of p16/Ki67 double staining detection (67.8%) of the patients in group A was significantly higher than that (29.8%) of the patients in group B and that (14.0%) of the patients in group C (P＜0.05). The sensitivity, the specificity, the positive predictive value, and the negative predictive value of the result of p16/Ki67 double staining detection of the patients for predicting their prognosis outcomes of cervical atypical squamous hyperplasia were 0.287, 0.760, 76.9%, and 40.7%, respectively. The canceration rate of the cervical atypical squamous hyperplasia (65.5%) of the patients in group 1 was significantly higher than that (2.7%) of the patients in group 2 (P＜0.05). The positive result of p16/Ki67 double staining detection of the patients were positively correlated with their progression rate of the cervical atypical squamous epithelial hyperplasia (P＜0.05). Conclusion: The result of p16/Ki67 double staining detection of the patients for predicting their prognosis outcomes of cervical atypical squamous hyperplasia has some clinical value.
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