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| Correlation between the levels of vitamins and trace elements in the peripheral blood of pregnant women during the third trimester of pregnancy and their neonatal growth and development |
| 1.Tiantai Hospital Traditional Chinese Medicine, Tiantai, Zhejiang Province, 317200；2. Taizhou Hospital, Zhejiang Province |
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Abstract To investigate the correlation between the levels of vitamins and trace elements in the peripheral blood of pregnant women during the third trimester of pregnancy and their neonatal growth and development. Methods: 45 pregnant women with fetal growth restriction (FGR) were enrolled in study group, and 45 pregnant women without FGR were included in control group from January 2019 to December 2021. The levels of vitamin A (Vit A), vitamin B12 (Vit B12), vitamin C (Vit C), vitamin E (Vit E), folic acid (FA), homocysteine (Hcy), and trace elements (calcium, iron, zinc, magnesium, copper) in the peripheral blood of the women in the two groups during the third trimester of pregnancy were detected. The neonatal birth body mass, length, head circumference, ponderal index (PI), and Apar in 10min after born were measured. The correlation between the levels of serum vitamins and trace elements of the women in the study group and the parameters of their neonatal growth and development was analyzed by Pearson correlation analysis. Results: The serum levels of Vit A, Vit B12, Vit C, Vit E, FA, calcium, iron, zinc, magnesium, and copper of the women in the study group were significantly lower than those of the women in the control group, while the Hcy level of the women in the study group was significantly higher than that of the women in the control group (all P<0.05). In the study group, the levels of Vit A, Vit B12, Vit C, Vit E, FA, calcium, iron, zinc, magnesium, and copper in peripheral blood of the women were significantly positively correlated with their neonatal birth weight, body length, head circumference, PI, and 10min Apar score, and the Hcy level of the women was significantly negatively correlated with their neonatal birth weight, body length, head circumference, PI, and Apar scores (P<0.05). Conclusion: There is a certain degree deficiency of vitamins and trace elements of the pregnant women during the third trimester of pregnancy, accompanied by the decreased FA level and the increased Hcy level, which may have a certain relationship with their neonatal adverse birth indexes. Strengthening the monitoring the levels of vitamins and trace elements, FA, and Hcy of the women before pregnancy is helpful for early evaluation and intervention of their FGR during pregnancy.
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