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| Predictive value of serum Metrnl and Perilipin 5 of pregnant women with gestational diabetes mellitus for their adverse pregnancy outcomes |
| The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhaung Autonomous Region, 530007 |
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Abstract To explore the levels of serum Metrnl and Perilipin 5 of pregnant women with gestational diabetes mellitus(GDM), and to study the predictive value of the levels of serum Metrnl and Perilipin 5 for the adverse pregnancy outcomes of these women. Methods: 107 pregnant women with GDM were selected in observation group and 50 healthy pregnant women who came to hospital for antenatal examination were selected in control group from September 2020 to August 2021. The levels of serum Metrnl and Perilipin 5 of the women in the two groups were detected by enzyme linked immunosorbent assay. The predictive value of the levels of serum Metrnl and Perilipin 5 of the women with GDM for their adverse pregnancy outcomes was evaluated by receiver operator characteristic(ROC) curve. The risk factors of the adverse pregnancy outcomes of the women with GDM were explored by multivariate logistic regression analysis. Results: The levels of serum Metrnl(125.17±13.54 pg/ml) and Perilipin 5(316.47±79.64 pg/ml) of the women in the observation group were significantly lower than those(164.82±22.65 pg/ml and 762.53±145.25 pg/ml) of the women in the control group. In the observation group, the levels of Metrnl and Perilipin 5 of the women with adverse pregnancy outcomes were significantly lower than those of the women with normal pregnancy outcomes(P<0.05). There were significant differences in the abortion history, the levels of low density lipoprotein, total cholesterol, triglyceride, fasting blood glucose, fasting insulin, and glycosylated hemoglobin, and the insulin resistance index value of the women between the two groups(P<0.05). ROC curve analysis showed that the area under curve(AUC) of the Metrnl level and the Perilipin 5 level of the women with GDM for predicting their adverse pregnancy outcomes were 0.846 and 0.813, the cut-off values of which were 119.53pg/ml and 337.84pg/ml, the specificity of which were 67.5% and 53.6%, and the sensitivity of which were 93.1% and 93.1%. The AUC, the specificity, and the sensitivity of the combined levels Metrnl and Perilipin 5 of the women with GDM for predicting their adverse pregnancy outcomes were 0.936, 85.0%, and 86.2%, respectively. Logistic regression analysis showed that the glycosylated hemoglobin level ≥6%, the HOMA-IR value ≥2.69, the Metrnl level ≤119.53 pg/ml, and the Perilipin 5 level ≤337.84 pg/ml of the pregnant women with GDM were the risk factors of their adverse pregnancy outcomes(P<0.05). Conclusion: The levels Metrnl and Perilipin 5 of the women with GDM are lowly expressed, and which can be used as the biological indicators for predicting the adverse pregnancy outcomes of the women.
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