|
|
|
| Levels of serum D dimer, nitric oxide, nitric oxide synthase of pregnant women with gestational diabetes mellitus and their prediction in the postpartum hemorrhage of the women |
| The Second People's Hospital of Jingmen , Hubei Province , 448000 |
|
|
|
|
Abstract To study the correlation between the levels of serum D dimer (D D), nitric oxide (NO), nitric oxide synthase (NOS) of pregnant women with gestational diabetes mellitus (GDM) and the risk of their postpartum hemorrhage (PH). Methods: The clinical data of 212 pregnant women with GDM from January 2019 to August 2021 were selected in this study. According to the occurrence of PH, these women were divided into group A (54 women with PH) and group B (158 women without PH). The levels of D D, NO, and NOS, and other general data of the women were compared between the two groups. The levels of serum D D, NO, and NOS of the women with GDM for predicting their PH was analyzed by receiver operator characteristic (ROC) curve, and the risk factors of PH of the women with GDM were analyzed by Logistic analysis. Results: The levels of D D (1628.32 ±69.55 mu g/L), NO (110.54 ±30.18 u mol/L),and NOS (26.78± 4.18 mm U/ml) of the women in group A were significantly higher than those (851.02±45.65μg/L, 2.15±10.60μmol/L, and 19.04± 4.03 U/ml) of the women in group B (all P<0.05). ROC curve analysis showed that the area under the curve of the levels of D D, NO, and NOS of the women with GDM for predicting their PH were 0.810, 0.820, 0.765, respectively, and the increase of the levels of D D, NO, and NOS of the women were their independent risk factors of PH. The D D level of the women with GDM was positively correlated with their NO and NOS levels, and the NO level of the women with GDM was positively correlated with their NOS level (P<0.05). Conclusion: The levels of serum D D, NO, and NOS of the women with GDM are related to their PH, and the abnormal increase of which have clinical values of the women with GDM for predicting their PH.
|
|
|
|
|
|
|
|
|
