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| Expressions of βhuman chorionic gonadotropin and inflammatory factor of patients with cesarean scar pregnancy after hysteroscopy treatment and their predictive values for the efficacy of hysteroscopy treatment |
| No. 990 Hospital of Joint Logistics Support Force, Zhumadian, Henan Province, 463000 |
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Abstract To explore the expressions of βhuman chorionic gonadotropin(β-hCG) and inflammatory factor of patients with cesarean scar pregnancy(CSP) after hysteroscopy treatment, and to study their predictive values for the efficacy of hysteroscopy treatment. Methods: 107 patients with CSP treated in hospital from June 2020 to June 2021 were analyzed retrospectively. According to the surgical treatment methods, these patients were divided into control group and study group. Uterine artery embolization was performed in 51 patients in the control group and scar lesion resection under hysteroscopy was performed in 56 patients in the study group. The levels of β-HCG before and after surgery and interleukin 6(IL-6) and tumor necrosis factor α(TNFα) in the 1st month after surgery of the patients in the two groups were detected. The predictive values of the levels of β-hCG, IL-6, and TNF α of the patients for their efficacy of hysteroscopy treatment was analyzed by receiver operator characteristic(ROC) curve. Results: The serum β-hCG level of the patients in the two groups in 72h after surgery was significantly lower than before surgery, and which of the patients in the study group was significantly lower than that of the patients in the control group. The IL-6 and TNF-α levels of the patients in the two groups in 1 month after surgery were significantly lower than those of the patients before surgery, and which of the patients in the study group were significantly lower than those of the patients in the control group(all P＜0.05). The sensitivity of the levels of β-hCG, IL-6, and TNF-α for predicting the curative effect of hysteroscopy treatment were 91.1%, 73.2%, and 87.5%, respectively, and the specificity of the levels of β-hCG, IL-6, and TNF-α for predicting the curative effect of hysteroscopy treatment were 82.4%, 80.4%, and 45.1%, respectively, and the areas under the curve of the levels of β-hCG, IL-6, and TNF-α for predicting the curative effect of hysteroscopy treatment were 0.956, 0.833, and 0.816, respectively. Conclusion: The expression levels of β-hCG and inflammatory factors of the patients with CSP increase abnormally and are reduced by the hysteroscopic treatment, and which have higher values for predicting the efficacy of hysteroscopic treatment.
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