To investigate the effects of different doses of dexmedetomidine combined with sevoflurane for anesthesia used during laparoscopic gynecological surgery of patients on their postoperative agitation. Methods: 96 patients who wanted elective laparoscopic gynecological surgery were selected and were randomly divided into three groups(32 cases in each group) from January 2020 to December 2021. The patients in group A and in group B were given 0.2μg/kg/h dexmedetomidine and 0.4μg/kg/h dexmedetomidine combined with sevoflurane for anesthesia, and the patients in group C were given 10 mL/h of normal saline combined with sevoflurane for anesthesia. The indexes of Anesthesia recovery, the dosage of anesthetic drugs, the hemodynamic changes, and the situations of postoperative sedation and agitation, and the adverse reactions of the patients in the three groups were observed. Results: The time of spontaneous respiration recovery, the awakening time, and the extubation time of the patients in group A were significantly shorter than those of the patients in group C and in group B. The Ramsay score of the patients in group B, group A, and group C had decreased gradually, and the Ricker sedation-2agitation score of the patients in group B(4.1±0.7 points) and in group A(4.3±0.9 points) was significantly lower than that(4.9±0.6 points) of the patients in group C. The dosage of sevoflurane of the patients in group B, in group A, and in group C had increased gradually(P＜0.05). The values of mean arterial pressure and heart rate of the patients in the three groups after anesthesia induction had decreased significantly, while those of the patients in the three groups at T2 and T3 had increased significantly, and which of the patients in group C, group A, and in group B had decreased gradually(all P＜0.05). The incidence(25.0%) of total adverse reaction, such as cough, chills, agitation, nausea and vomiting, of the patients in group A(25.0%) and in group B(15.6%) were significantly lower than that(50.0%) of the patients in group C(P＜0.05). Conclusion: Dextrmetomidine combined with sevoflurane for anesthesia used during laparoscopic gynecological surgery of the patients can effectively reduce their incidences of postoperative agitation and adverse reactions, and can reduce the dosage of sevoflurane. The low dose dexmedetomidine of 0.2μg/kg/h will not prolong the time of anesthesia recovery of the patients, with the stable hemodynamic indexes.