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| Effects of thyroid hormone for treating pregnant women with subclinical hypothyroidism on the growth and development of offspring of the women |
| 1.Tang Shan Hongci Hospital, Tangshan, Hebei Province, 063000; 2.Kailuan Hospital, Tangshan, Hebei Province |
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Abstract To investigate the effects of thyroid hormone for treating pregnant women with subclinical hypothyroidism(SCH) on the growth and development of offspring of the women. Methods: 240 pregnant women were selected and were divided into control group(175 normal pregnant women) and study group(65 pregnant women with SCH) according to the results of their thyroid function screening. The women in the study groups received the treatment of levothyroxine(LT4). The changes of thyroid function indexes and the pregnancy outcomes of the women in the two groups were observed. The physical and mental development of the offspring aged 0-24 months of the women were compared between the two groups. Results: There were no significant differences in the levels of free thyroxine(FT4) and free triiodothyronine(FT3) of the women during the gestational week at the first visiting the doctor, or during the 26th or 36th gestational week between the two groups(P>0.05). The levels of serum thyroid stimulating hormone(TSH) and thyroid peroxidase antibody(TPO-Ab) of the women in the study group during the 26th or 36th gestational week were significantly lower than those of the women during the gestational week at the first visiting the doctor(P＜0.05). The levels of TSH and TPO-Ab of the women in the study group during the gestational week at the first visiting the doctor, or during the 26th or 36th gestational week were significantly higher than those of the women in the control group(P＜0.05). There was no significant difference in the total incidence of the adverse pregnancy outcomes(4.6% vs. 4.0%) of the women between the two groups(P>0.05). There were no significant differences in the double parietal diameter of the fetus, the height and weight of the offspring at birth, age of 1 month old, age of 6 months, and age of 12 months, and the developmental quotient and the abnormal rate of the developmental quotient of the grand motor, fine motor, adaptive ability, language, and social behavior of the offspring age of 24 month between the two groups(P>0.05). Conclusion: Early thyroid hormone therapy for the pregnant women with SCH is helpful to prevent the occurrence of their adverse pregnancy outcomes, and is beneficial to the physical and neuro intellectual development of their offspring. The short-term physical and neuro intellectual development levels of the offspring of the pregnant women with SCH is equivalent to those of the offspring of the pregnant women with normal thyroid function.
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