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| Clinical efficacy analysis of nifedipine combined with labetalol for treating pregnant women with hypertensive disorder complicating pregnancy |
| Jincheng Second People's Hospital, Jincheng, Shanxi Province, 048000 |
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Abstract To explore the clinical efficacy analysis of nifedipine combined with labetalol for treating pregnant women with hypertensive disorder complicating pregnancy(HDCP), and to analyze its mechanism. Methods: 119 pregnant women with HDCP were selected and were divided into observation group(60 cases) and control group(59 cases) by random number table from February 2019 to December 2021. The women in the control group were treated with labetalol for 1 week, and the women in the observation group were treated with nifedipine combined with labetalol for 1 week. The clinical efficacy, the blood pressure value, the values of uterine artery hemodynamics, such as resistance index(RI), pulsation index(PI), and ratio of maximum blood flow velocity(S/D) in systolic and diastolic period, and the adverse pregnancy outcomes of the women were compared between the two groups. Results: After treatment, the total effective rate(95.0%) of the women in the observation group was significantly higher than that(81.4%) of the women in the control group. The values of systolic blood pressure(126.7±12.3 mmHg), diastolic blood pressure(77.8±5.8 mmHg), RI(0.45±0.04), PI(0.63±0.07), and S/D(1.78±0.12) of the women in the observation group were significantly lower than those(133.1±13.2 mmHg, 82.2±4.7 mmHg, 0.57±0.05, 0.75±0.08, and 1.96±0.15) of the women in the control group. The incidences of cesarean section(33.3%) and preterm delivery(13.3%) of the women in the observation group were significantly lower than those(54.2% and 28.8%) of the women in the control group(all P＜0.05). Conclusion: Nifedipine combined with labetalol for treating the pregnant women with HDCP can effectively reduce their blood pressure and improve their pregnancy outcomes, the main mechanism of which is related to the further regulate the uterine artery hemodynamics of the women.
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