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| Diagnostic value of magnetic resonance imaging combined with the levels of serum soluble FMS like tyrosine kinase-1 and alpha fetoprotein of pregnant women for their placenta previa with placenta accreta |
| Shiyan People's Hospital（Affiliated People's College of Hubei University of Medicine）, Hubei Province, 442000 |
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Abstract To analyze the diagnostic value of the results of magnetic resonance imaging (MRI) combined with the levels of serum soluble FMS like tyrosine kinase-1 (sFlt1) and alpha fetoprotein (AFP) of pregnant women for their placenta previa and placenta accreta. Methods: The clinical data of 278 pregnant women with suspected placenta previa and placenta accreta from January 2021 to January 2022 were collected. 142 women with confirmed placenta previa and placenta accreta based on pathological examination were included in study group, and another 136 health pregnant women were included in control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the serum sFlt-1 and AFP levels. Pearson method was used to analyze the correlation between the serum sFlt-1 level of the women in the study group and their AFP level. The pathological results were as the gold standard of dognosing placenta previa and placenta accreta, the diagnostic efficacy of MRI results and the serum sFlt-1 and AFP levels of the women for their placenta previa and placenta accreta was analyzed. Results: The levels of sFlt-1 (2.52±0.43 ng/ml) and AFP (62.91±7.19 U/ml) of the women in the study group were significantly higher than those (1.12±0.15 ng/ml and 30.72±3.57 U/ml) of the women in the control group. The expression levels of serum sFlt-1 and AFP of the women with adhesion, penetration, and implantation of placenta accreta in the study group had increased gradually (all P＜0.05). The serum sFlt-1 level of the women in the study group was positively correlated with their AFP level (P＜0.05). The proportions of uneven signal in placenta, the thickened blood vessel shadow in placenta, the unclear boundary between the placenta and the uterus of the women in the study group were significantly higher than those of the women in the control group, and the proportions of the bladder protrusion and local exudation of the uterus of the women in the study group were significantly lower than those of the women in the control group (all P＜0.05). The sensitivity (84.8%) and the accuracy (80.2%) of the results of MRI combined with the serum sFlt-1 and AFP levels of the women for diagnosing their placenta previa and placenta accreta were significantly higher than those of the results of MRI, the serum sFlt-1 level, or the AFP level alone. Conclusion: The levels of serum sFlt-1 and AFP of the pregnant women with placenta previa and placenta accreta are increased abnormally. The results of MRI combined with the serum sFlt-1 and AFP levels of the women for diagnosing their placenta previa and placenta accreta can improve the sensitivity.
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