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| Analysis of the influence factors of chromosome abnormality in chorionic villus after spontaneous abortion of infertile patients with assisted reproductive technology |
| 1.The Third People's Hospital of Baoji, Shaanxi Province, 721000; 2. The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province; 3. The Affiliated Hospital of Shaanxi University of traditional Chinese medicine, Xianyang, Shaanxi Province |
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Abstract To analyze the factors of chromosome abnormality in chorionic villus after spontaneous abortion of infertile patients with assisted reproductive technology (ART). Methods: From April 2018 to March 2020, 113 infertile patients with spontaneous abortion after ART treatment were collected. The patients were divided into study group (n=61) and control group (n=52) according to the results of G-banding karyotype analysis of chorionic villus tissue. The occurrence and type of chromosome abnormality in chorionic villus tissue, and the risk factors of the chromosome abnormality of the patients were analyzed. Results: Among 113 patients, there were 61 cases with abnormal chromosome, and the incidence was 54.0%. Among them, the triploid of chromosome accounted for the highest proportion (59.0%). The incidence of chromosome abnormality of the patients with 36-50 years old was significantly higher than that of the patients with 20-35 years old, and which of the patients with spontaneous abortion ≥3 times was significantly higher than that of the patients with spontaneous abortion 2 times (all P＜0.05). There was no significant difference in the incidence of chromosome abnormality between the patients with and without mycoplasma infection, among the patients with different times of uterine operation before ART, or among the patients with different methods of embryo transfer (P＞0.05). The advanced age and the spontaneous abortion ≥3 times of the patients with ART were the factors of their chromosome abnormality in villus tissues after spontaneous abortion (P＜0.05). Conclusion: The advanced age and the times of spontaneous abortion of the patients with ART are the risk factors of their chromosome abnormality in villus tissues.
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