|
|
|
| Changes of T lymphocyte subsets and NK cells in peripheral blood of pregnant women with severe preeclampsia and their effects on the maternalinfant outcomes |
| Guang'an People's Hospital, Guang'an, Sichuan Province, 638000 |
|
|
|
|
Abstract To explore the changes of T lymphocyte subsets and NK cells (NK) in peripheral blood of pregnant women with severe preeclampsia (PE) and their effects on the maternal-infant outcomes. Methods: 91 pregnant women with severe PE were included in this study and were divided into group A (42 women with earlyonset severe PE) and group B (49 women with late-onset severe PE) according to the onset time of PE from June 2020 to June 2022. The levels of T lymphocyte subsets and NK cells in peripheral blood, and the maternal-infant outcomes of the women were compared between the two groups. The correlation between T lymphocyte subsets and NK cells levels of the women and their onset time of PE with severe PE was analyzed. Results：There were no statistical significant differences in the levels of CD3+ and CD4+ in peripheral blood of the women between the two groups (P＞0.05). The levels of CD8+ and NK cells of the women in group A were significantly higher than those of the women in group B, while the CD4+/CD8+ level of the women in group A was significantly lower (P＜0.05). The levels of CD8+ and NK cells in peripheral blood of the women were negatively correlated with their onset time of PE (r=-0.397,-0.340, P＜0.05), and the CD4+/CD8+ ratio of the women was positively correlated with their onset time of PE (r=0.481, P＜0.05). The rate of natural delivery of the women in group A was significantly lower than that of the women in group B, and the rates of cesarean section, premature delivery, placental abruption, intrauterine growth retardation, and fetal distress of the women in group A were significantly higher (P＜0.05). Conclusion: T lymphocyte subsets and NK cells in peripheral blood of the women may participate in the progression of their severe PE. High levels of CD8+and NK cells of the women are more likely to cause their early-onset severe PE.
|
|
|
|
|
|
|
|
|
