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Abstract To investigate the correlation between the hepatitis B virus (HBV) infection of reproductive-aged women and their impaired fasting glucose (IFG) and diabetes mellitus (DM). Methods: Cross-sectional survey method was conducted on the reproductive-aged women who had participated in the National Free Preconception Health Checkup Project and had completed the risk assessment from January 2015 to December 2017. Basic demographic characteristics, lifestyles, family history, disease history, height, weight, blood pressure, fasting blood glucose, hepatitis B serological test results, and other information of these women were collected. Multiple logistic regression analysis was used to analyze the correlation between the HBV infection of the reproductive-aged women and their IFG and DM. Results: In the study population, the detection rates of HBV infection, IFG, and DM were 7.7%, 3.2%, and 1.5%, respectively. After adjusting for age, educational level, occupation, region, family history of DM, tobacco exposure, alcohol consumption, hypertension, and body mass index (BMI), HBV infected reproductive-aged women were 23% more likely to have IFG (OR=1.23, 95% CI: 1.22-1.25) and 40% more likely to have DM (OR=1.40, 95% CI: 1.37-1.42), respectively, compared with those of the non-HBV infected women. The stratification analysis for all these research objects showed that the correlation between the HBV infection of reproductive-aged women with family history of DM, alcohol consumption, or hypertension and their IFG and DM had no statistical significant differences, and the other subgroups analysis suggested that the rates of IFG and DM of the reproductive-aged women with HBV infection were significantly higher than those of the women without HBV infection. Conclusion: The HBV infection of the reproductive-aged women increases the risk of their IFG and DM, but even the HBV-infected women who were aged <35 years old, had no family history of DM, no tobacco exposure, no alcohol consumption, non-hypertension, or were normal BMI value should also be paid more attention to their blood glucose levels pre-pregnancy and during pregnancy.
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