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| Correlation between the persistent human papillomavirus infection of puerperae and their reproductive tract microbial level and adverse pregnant outcomes |
| 1. Hainan Modern Women and children's Hospital, Haikou, Hainan Province, 571100; 2. The Second Affiliated Hospital of Hainan Medical University |
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Abstract To study the correlation between the persistent human papillomavirus (HPV)infection of puerperae and their reproductive tract microbial level and their maternal and infant adverse pregnant outcomes. Methods: 460 puerperae who had undergone antenatal examination from January 2019 to January 2021 were selected as the research objects, and which including 105 puerperae with HPV infection in group A and 355 puerperae without HPV infection in group B. In group A, 50 puerperae with HR-HPV in group A1 and 55 puerperae with other HPV in group A2. The differences of vaginal microorganisms and the pregnancy outcomes of the puerperae were compared between group A and group B, and between group A1 and group A2. The correlation between the HPV and HR-HPV infections of the puerperae and their vaginal flora and pregnancy outcomes was analyzed. Results: There were significant differences in the intensity, diversity, and microecology of vaginal flora of the puerperae among group B, group A1, and group A2. The incidences of premature delivery, the premature rupture of membranes, and the fetal growth restriction and respiratory distress syndrome of the puerperae in group A were significantly higher than those of the puerperae in group B. Correlation analysis showed that the HPV and HR-HPV infection of the puerperae were positively correlated with their intensity, diversity, and microecology of vaginal flora, the preterm birth, the premature rupture of membranes, and the fetal growth restriction and the respiratory distress syndrome (P＜0.05). Conclusion: The persistent HPV infection of the puerperae is correlation with their reproductive tract microbial level and their maternal and infant outcomes significantly. It is suggested that maternal HPV testing of the puerperae should be carried out regularly.
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