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| Levels of serum human AHSG and pregnancy-associated plasma protein-A of pregnant women with gestational diabetes mellitus and their correlation with the pregnancy outcomes |
| 1.Qinhuangdao Maternal and Child Health Care Hospital, Hebei Province, 066000；2.Qinhuangdao First Hospital |
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Abstract To analyze the levels of serum human AHSG and pregnancy-associated plasma protein-A (PAPP-A)of pregnant women with gestational diabetes mellitus, and to study their correlation with the pregnancy outcomes of the women. Methods: A total of 102 pregnant women with GDM were selected in research group, 102 healthy pregnant women were selected in control group between February 2018 and February 2021. The level of serum AHSG was detected by enzyme-linked immunosorbent assay, and the level of serum PAPP-A was detected by immunofluorescence assay. The predictive value of the serum AHSG and PAPP-A levels of the women for GDM was analyzed by receiver operating characteristic (ROC)curve. The correlation between the levels of serum AHSG and PAPP-A of the women and their pregnancy outcomes was analyzed by Pearson analysis. Results: The level of serum AHSG (263.07±53.28μg/L)of the women in the research group was significantly higher than that (173.94±47.51μg/L)of the women in the control group, and the level of PAPP-A (21.42±1.47 ng/ml)of the women in the research group was significantly lower than that (26.05±1.39 ng/ml)of the women in the control group. In the research group, the level of serum AHSG of the women with adverse pregnancy outcomes was significantly higher than that of the women with normal pregnancy outcomes, and the level of PAPP-A of the women with adverse pregnancy outcomes was significantly lower. The level of serum AHSG level of the women in the research group was positively correlated with their adverse pregnancy outcomes (r=0.215), and the PAPP-A level of the women in the research group was negatively correlated with their adverse pregnancy outcomes (r=-0.757)(all P＜0.05). ROC analysis showed that the area under the curve of the serum AHSG level, the PAPP-A level, and the combined levels of AHSG and PAPP-A of the women for predicting their GDM were 0.784, 0.724, and 0.844, respectively. Conclusion: The levels of serum AHSG and PAPP-A of the pregnant women with GDM are abnormal, and which are correlated with the adverse pregnancy outcomes. The detections of the serum AHSG and PAPP-A levels of the women have certain clinical value for predicting the occurrence of their GDM, and which provide guidance for the clinical intervention of GDM timely.
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