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| Levels of inhibin B, anti-Mullerian hormone, and basal follicle stimulating hormone of women with infertility induced by polycystic ovary syndrome and their evaluative values for ovarian reserve function |
| 1. Fengdu County Hospital of Traditional Chinese Medicine, Chongqing, 408200；2. Pengshui Miao and Tujia Autonomous County Hospital of Traditional Chinese Medicine, Chongqing |
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Abstract To explore the evaluative values of the levels of inhibin B(INHB), anti-Mullerian hormone (AMH), and basal follicle stimulating hormone (bFSH)of women with infertility induced by polycystic ovary syndrome (PCOS)for their ovarian reserve function. Methods: A total of 87 women with PCOS induced infertility (in study group)and 53 healthy women (in control group)between October 2019 and October 2020 were collected respectively. The levels of serum INHB, AMH, and bFSH of the women in the two groups were detected. According to the number of retrieved oocytes, the women in the study group were divided into group A (women with ovarian low response)and group B (women with normal ovarian response). And the levels of serum INHB, AMH, and bFSH of the women for evaluating their ovarian reserve function was analyzed. Results: The levels of serum INHB (149.78±36.92 pg/ml)and AMH (10.94±3.21 ng/ml)of the women in the study group were significantly higher than those (96.85±31.29 pg/ml and 3.29±0.95 ng/ml) of the women in the control group. The bFSH level (13.08±3.41 IU/L)of the women in the study group was significantly lower than that (16.29±4.74 IU/L)of the women in the control group. The serum INHB and AMH levels of the women in group A were significantly higher than those of the women in group B, but the bFSH level of the women in group A was significantly lower (all P＜0.05). Pearson correlation analysis showed that in the study group, the serum INHB level of the women was positively correlated with their AMH level (r=0.516)and was negatively correlated with their bFSH level (r=-0.637), and the AMH level of the women was negatively correlated with their BFSH level (r=-0.453)(all P＜0.05). The receiver operator characteristic curve showed that the area under the curve (AUC)of the serum INHB, AMH, and bFSH levels of the women for evaluating their ovarian reserve function were 0.726, 0.774, and 0.695, respectively, and the AUC of the combined detections of serum INHB, AMH, and bFSH levels of the women for evaluating their ovarian reserve function was 0.887, with the sensitivity of 92.3%. Conclusion: The levels of INHB, AMH, and bFSH of the women with PCOS induced infertility are abnormal, which are of certain predictive values for predicting their ovarian reserve function. The combinations of serum INHB, AMH, and bFSH levels of the women can increase the value for evaluating their ovarian reserve function.
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