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| Effects of dexmedetomidine on the oxytocin-induced uterine contractions of women delivered by cesarean section |
| Wenzhou Central Hospital, Wenzhou, Zhejiang Province, 325000 |
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Abstract To investigate the effects of dexmedetomidine on the oxytocin-induced uterine contractions of women delivered by cesarean section. Methods: 96 women who underwent cesarean section were selected and were divided in two groups (48 cases in each group)from February 2021 to June 2022. During cesarean section, the women in the study group were given intravenous administration of dexmedetomidine and the women in the control group were given normal saline. The values of heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP), the scores of VAS and Ramsay, and the uterine contraction intensity of the women in the two groups before anesthesia (T0), at 10 min after anesthesia (T1), at 10 min after dexmedetomidine (T2), and at the end of surgery (T4)were evaluated. The occurrence of intraoperative adverse reactions of the women in the two groups was recorded. Results: The values of HR, SBP, and DBP of the women in the two groups fluctuated at T1, T2, and T3, especially the women in the study group, and which of the women in the study group were significantly more than those of the women in the control group. The VAS scores of the women in the study group at T2 and T3 (0.78±0.51 points and 0.88±0.41 points)were significantly lower than those (2.08±1.01 points and 2.45±0.87 points)of the women in the control group. The Ransay score of the women in the study group at T2 and T3 (2.45±1.04 points and 2.41±0.78 points)were significantly higher than those (1.47±0.88 points and 1.45±0.55 points)of the women in the control group (all P＜0.05). There was no significant difference in the uterine contraction score of the women between the two groups (P＞0.05). The incidences of nausea (10.4%), vomiting (2.1%), and hypotension (27.1%)of the women in the study group were significantly lower than those (39.6%, 12.5%, and 58.3%)of the women in the control group, and the incidence of bradycardia (62.5%)of the women in the study group was significantly higher than that (31.3%)of the women in the control group (all P＜0.05). Conclusion: Dexmedetomidine has no significant effect on the oxytocin-induced uterine contractions of the women during cesarean section, and which has better analgesic and sedative effect, and is beneficial to reduce the occurrence of complications of the women.
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