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| Effects of intranasal or intravenous injection dexmedetomidine during gynecological laparoscopic surgery of patients on their intraocular pressure and hemodynamics |
| 1. Shanghai Eighth People's Hospital, Shanghai, 200235；2. Shanghai Fifth People's Hospital, Shanghai |
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Abstract To investigate the effects of intranasal dexmedetomidine or intravenous injection dexmedetomidine during gynecological laparoscopic surgery of patients on their intraocular pressure (IOP)and hemodynamics. Methods: From January 2019 to December 2021, 115 patients who wanted gynecological laparoscopic surgery were randomly divided into three groups by random number table method. The patients in group A were given intranasal dexmedetomidine (0.6μg/kg), the patients in group B were given continuous intravenous infusion of dexmedetomidine (0.6μg/kg), and the patients in group C were given intranasal 0.9% normal saline. The values of mean arterial pressure (MAP), heart rate (HR)， and intra-ocular pressure (IOP), and the adverse reactions rate in the perioperative period of the patients in the three groups before anesthesia induction (T0), at 5 minutes after anesthesia induction (T1), at 5 minutes after tracheal intubation (T2), at 30 minutes after pneumoperitoneum and body position change (T3), and at tracheal extubation (T4)of the patients in the three groups were observed and recorded. Results: The values of MAP, OP, and HR of the patients in the three groups at T1 were significantly lower than those of the patients at T0. The values of MAP, IOP, and HR of the patients in group C at T2-T4 were significantly higher than those at T0, and which of the patients in group C, group A, and group B had decreased gradually (all P＜0.05). The incidence of ocular hypertension (5.3% or 2.6%)of the patients in group A or group B was significantly lower than that (23.1%)of the patients in group C, while the incidences of hypotension (20.1%)and bradycardia (15.8%)of the patients in group B were significantly higher than those (0 and 0)of the patients in group C and those (5.3% and 2.6%)of the patients in group A (all P＜0.05). Conclusion: Dexmedetomidine is helpful to stabilize the hemodynamics of the patients during gynecologic laparoscopic surgery under anesthesia, and which can reduce the risk of the IOP elevating. Intranasal dexmedetomidine is safer than intravenous injection of dexmedetomidine.
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