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| Expressions and clinical significances of MiR-1287-5p and homeobox A7 in cervical cancer tissues of patients |
| 1.Shengbao Maternity Hospital of Beijing, Beijing, 100089；2.Yuquan Hospital of Tsinghua University |
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Abstract To explore the expressions and clinical significance of miR-1287-5p and homeobox A7 (HOXA7) in cervical cancer of patients. Methods: The clinical data of 92 patients with cervical cancer from June 2013 to January 2017 were collected in this study. The expression of miR-1287-5p and HOXA7 in cervical cancer tissue and in paracancerous tissue were detected by qRT-PCR. Pearson analysis was applied to analyze the correlation between the MiR-1287-5p level in cervical cancer tissues of the patients and their HOXA7 expression level. Kaplan-Meier survival curves were applied to analyze the correlation between the MiR-1287-5p and HOXA7 expression levels of the patients with cervical cancer and their prognosis. COX regression was applied to analyze the risk factors affecting the prognosis of the patients with cervical cancer. Results: The miR-1287-5p level (0.71±0.16) in cervical cancer tissue was significantly lower than that (1.03±0.05) in paracarcinoma tissue, and the HOXA7 mRNA level (1.51±0.24) was significantly higher than that (1.02±0.03) in paracarcinoma tissue (all P＜0.05). The miR-1287-5p level in cervical cancer tissue was negatively correlated with the HOXA7 level (r=-0.484, P＜0.05). The MiR-1287-5p and HOXA7 expression levels in cervical cancer tissue of the patients were associated with their human papillomavirus (HPV) infection, their lymph node metastasis, their differentiation status of cancer, and their FIGO staging (P＜0.05). Kaplan-Meier analysis showed that the survival rate of the patients with high MiR-1287-5p expression level was significantly higher than that of the patients with low Mir-1287-5p expression level (logrank=12.471, P=0.000), and the survival rate of the patients with low HOXA7 expression level was significantly higher than that of the patients with high Mir-1287-5p expression level (logrank=5.180, P=0.023). Multivariate COX regression analysis showed that the positive HPV infection, the low tissue differentiation of cancer, the FIGO stage Ⅲ-Ⅳ of cancer, the low expression level of Mir-887-5p, and the high expression level of HOXA7 of the patients with cervical cancer were the independent risk factors of their poor prognosis (P＜0.05). Conclusion: The expression level of miR-1287-5p in cancer tissues of the patients decreases, and the expression level of HOXA7 in cancer tissues of the patients increases, and the abnormal expression levels of both which influence the prognosis of the patients with cervical cancer.
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