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| Levels of the serum ferritin and homocysteine of pregnant women with subclinical hypothyroidism and the effect of levothyroid hormone replacement therapy |
| 1.Huaian Clinical College, Xuzhou Medical University, Huaian, Jiangsu Province, 223300；2.Huaian Maternal and Child Health Care Hospital, Jiangsu Province |
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Abstract To explore the changes of the levels of the serum ferritin and homocysteine (Hcy) of pregnant women with subclinical hypothyroidism (SCH), and to study the effect of levothyroid hormone replacement therapy. Methods: From March 2019 to December 2021, 104 pregnant women with SCH were included in group A and 110 pregnant women with normal thyroid function were selected in group B. The levels of serum ferritin, Hcy, and thyroid function indexes of the women were compared between the two groups. The correlation between serum ferritin and Hcy of the women and their thyroid function indexes levels was analyzed by simple linear correlation analysis. The changes of the levels of serum ferritin, Hcy, and thyroid function indexes of the women in group A before and after levothyroxine replacement therapy were observed. Results: The levels of serum Hcy (14.39±3.80μmol/L), thyroid stimulating hormone (TSH, 4.40±1.26 mU/L), thyroid peroxidase antibody (TPOAb,11.74±2.60 IU/ml) of the women in group A were significantly higher than those (11.64±3.11 μmol/L, 1.69±0.66 mU/L, and 5.71±1.13 IU/ml) of the women in group B (all P＜0.05). There were no significant differences in the levels of ferritin, thyroxin (FT4), and free triiodothyronine (FT3) of the women between the two groups (P＞0.05). The levels of serum ferritin and Hcy of the women in group A were not correlated with the levels of their serum TSH, FT3, FT4, and TPOAb (P＞0.05). The levels of serum Hcy and TSH of the women in group A had decreased significantly after levothyroxine replacement therapy (P＜0.05). Conclusion: The Hcy level of the pregnant women with SCH increases abnormally. Levothyroxine replacement therapy can improve the thyroid function indicators and Hcy level of the women with SCH.
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