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| Effect of dexmedetomidine combined with butorphanol for postoperative analgesia of women after cesarean section and its influence on the stress response of these women |
| 1.Funan County People Hospital, Fuyang, Anhui Province, 236300; 2. The First Affiliated Hospital of Bengbu Medical College |
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Abstract To investigate the effect of dexmedetomidine combined with butorphanol for postoperative analgesia of women after cesarean section, and to study its influence on the stress response of these women. Methods: From January 2021 to June 2022, a total of 92 pregnant women who wanted elective cesarean section were selected and were randomly divided into two groups (46 cases in each group). The women in the control group were given 10mg butorphanol for postoperative self-controlled analgesia, and the women in the study group were given 0.5μg/kg dexmedetomidine by intravenous pump after baby delivery and then dexmedetomidine 0.2 μg/kg /h combined with 10mg butorphanol for postoperative self-controlled analgesia. The scores of visual analogue scales (VAS) and Ramsay, and stress response indexes of the women at different time points after cesarean section were compared between the two groups. And the situation of postoperative adverse reactions of the women in the two groups were recorded. Results: There were no significant differences in the scores of VAS and Ramsay, and the levels of serum stress response indexes of the women after cesarean section between the two groups (P＞0.05). The VAS score of the women in the study group at postoperative 12h, 24h and 48h were 2.03±0.54 points, 1.60±0.46 points, and 1.27±0.45 points, respectively, which were significantly lower than those (2.32±0.62 points, 1.95±0.5 points, and 1.62±0.49 points) of the women in the control group. The Ramsay score of the women in the study group at postoperative 12h, 24h and 48h were 2.02±0.46 points, 2.12±0.58 points, and 2.71±0.59 points, respectively, which were significantly higher than those (1.98±0.43 points, 2.53±0.61 points, 2.96±0.57 points) of the women in the control group. The levels of serum norepinephrine (272.20±24.84 pg/ml), endothelin-1 (73.32±10.05 pg/ml), and cortisol (266.32±32.05 ng/ml) of the women in the study group at postoperative 12h were significantly lower than those (317.75±25.19 pg/ml and 79.57±10.62 pg/ml, and 297.57±34.62 ng/ml) of the women in the control group. The incidences of vertigo (10.9%), and nausea and vomiting (4.4%) of the women in the study group after operation were significantly lower than those (32.6% and 21.7%) of the women in the control group (all P＜0.05). Conclusion: Application of dexmedetomidine combined with butorphanol for postoperative self-controlled analgesia of the women after cesarean section can achieve satisfactory analgesic and sedative effects, and which can alleviate the stress reaction of the women, with fewer adverse reactions.
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