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| Analysis of the risk factors of ectopic pregnancy and the effect of mifepristone combined with methotrexate for treating women with ectopic pregnancy |
| 1. Linhai Hospital of traditional Chinese Medicine Clinical Laboratory Linhai, Zhejiang Province, 317000；2. Taizhou hospital of Zhejiang |
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Abstract To analyze the risk factors of ectopic pregnancy of women, to investigate the clinical efficacy of mifepristone combined with methotrexate for treating these women, and to study its influence on the expressions of their serumβ-human chorionic gonadotropin (β-hCG) and carbohydrate antigen 125 (CA125). Methods: A total of 96 women with ectopic pregnancy (in group A) and 125 women with normal intrauterine pregnancy (in group B) were selected as the research objects from March 2019 to January 2021. The women in group A were divided into two groups according to different treatment methods, which included 48 women with treatment of mifepristone combined with methotrexate in group A1 and 48 women with treatment of methotrexate alone in group A2. Logistic regression model was used to analyze the risk factors of ectopic pregnancy. The results of pregnancy termination, the levels of β-hCG and CA125, and the pregnancy after 1 year and 6 months of follow-up of the women were compared between group A1 and group A2. Results: There were no significant differences in the marital status, the drinking history, the history of intrauterine device inserted, and the drug contraceptive history of the women between group A and group B (P＞0.05), but there were significant differences in the pregnancy history, the induced abortion history, the infertility history, the smoking history, the number of sexual partners, the gynecological inflammation history, and the pelvic operation history of the women between group A and group B (P＜0.05). Binary logistic regression analysis showed that the pregnancy history, the abortion history, the infertility history, the smoking history, the gynecological inflammation history, the pelvic surgery history, and ≥2 sexual partners were the independent risk factors of the ectopic pregnancy of the women (P＜0.05). In group A, the success rate of pregnancy termination (89.6%) of the women in group A1 was significantly higher than that (70.8%) of the women in group A2 (P＜0.05). After treatment, the serum β-hCG and CA125 levels of the women in group A1 were significantly lower than those of the women in group A2 (P＜0.05), and there were no significant differences in the rates of the intrauterine pregnancy (81.3% vs.72.9%), the ectopic pregnancy (6.3% vs.10.4%), and the secondary infertility (2.1% vs. 6.3%) of the women in 1.5 year after operation between group A1 and group A2 (P＞0.05). Conclusion: The pregnancy history, the abortion history, the infertility history, the smoking, the gynecological inflammation history, the pelvic operative history, and the sexual partners ≥2 of the women were the risk factors of their ectopic pregnancy. Mifepristone combined with methotrexate for treating the women with ectopic pregnancy can increase the effect of the treatment, which is beneficial to reduce the levels of β-hCG and CA125 of the women, with better safety.
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