|
|
|
| Influence of intrauterine perfusion of platelet rich plasma and granulocyte colony stimulating factor for treating patients with thin endometrium on their uterine spiral artery flow and outcomes of in vitro fertilization embryo transfer |
| 1.Haikou Mary Hospital, Haikou, Hainan Province, 570100; 2.928th Hospital of PLA Joint Logistics Support Force, Hainan Province |
|
|
|
Abstract To analyze the influence of intrauterine perfusion of platelet rich plasma (PRP) and granulocyte colony stimulating factor (G-CSF) for treating patients with thin endometrium on their uterine spiral artery flow and outcomes of in vitro fertilization embryo transfer (IVF-ET). Methods: 147 patients with thin endometrium who had undergone IVF-ET between January 2019 and January 2022 were collected retrospectively. These patients were divided into two groups according to different treatment methods. 72 patients in group A were treated with PRP intrauterine perfusion, and 75 patients in group B were treated with G-CSF intrauterine perfusion. The uterine spiral artery flow spectrum, the endometrial thickness, the endometrial morphology classification, and the change of blood flow classification before and after treatment of the patients were compared between the two groups. The clinical pregnancy rate, the early abortion rate, the embryo implantation rate, the number of transferred embryos, and the number of high-quality embryos of the patients in the two groups were analyzed statistically. Results: The values of peak systolic velocity (PSV), the peak diastolic velocity (EDV), the peak systolic velocity/peak diastolic velocity (S/D), the resistance index (RI), and the pulse index (PI) of the patients in the two groups after treatment had decreased significantly. The thickness of endometrium of the patients in the two groups after treatment had increased significantly. The proportions of type A and type B of endometrial morphology of the patients in the two groups after treatment had increased significantly, and the proportion of type C of the endometrial morphology of the patients in the two groups after treatment
had decreased significantly (P<0.05). The proportion of endometrial blood flow type Ⅰ of the patients in the two groups after treatment had decreased significantly, and the proportions of endometrial blood flow type Ⅱ and Ⅲ of the patients in the two groups after treatment had increased significantly (all P<0.05). There were no significant differences in the values of PSV, EDV, S/D, RI, and PI, the thickness of endometrium, the proportions of type A, type B, and of type C, and the proportions of endometrial blood flow type Ⅰ, type Ⅱ, and Ⅲ of endometrial morphology of the patients between the two groups (P>0.05). There were no significant differences in the rates of clinical pregnancy, the early abortion, the rate of embryo implantation, the embryo transfer number, and the number of the high-quality embryo of the patients after IVF-ET between the two groups (P>0.05). Conclusion: Both intrauterine perfusion of PRP and G-CSF for treating the patients with thin endometrium after IVF-ET can improve their blood flow spectrum of uterine spiral artery and promote their endometrial growth, and both of which have the equivalent efficacy and have no different in the outcome indicators of the patients after IVF-ET.
|
|
|
|
|
|
|
|
|
