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| Correlation between the menstrual pattern of patients with polycystic ovary syndrome and their sex hormones levels and glucolipid metabolism |
| Chongqing Fengdu People's Hospital, Chongqing, 408200 |
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Abstract To investigate the correlation between the menstrual pattern of patients with polycystic ovary syndrome(PCOS) and their sex hormones levels and glucolipid metabolism. Methods: A total of 126 patients with PCOS from May 2021 to May 2022 were selected in this study retrospectively. According to the menstrual pattern, these patients were divided into group A(patients with regular menstruation) and group B(patients with irregular menstruation, including frequent menstruation, infrequent menstruation, and amenorrhea). The levels of serum testosterone(T), luteinizing hormone(LH), follicle stimulating hormone(FSH), estradiol(E2), free androgen index(FAI), prolactin(PRL), anti-Müllerian hormone(AMH), fasting plasma glucose(FPG), homeostatic model assessment for insulin resistance(HOMA-IR), total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), and low-density lipoprotein cholesterol(LDL-C) of the patients were compared between these groups. The correlation between the menstrual pattern of the patients with PCOS and their sex hormones levels and glucolipid metabolism was analyzed. Results: The levels of T, E2, AMH, TC, and TG, and the values of LH/FSH and HOMA-IR of the patients in group B were significantly higher than those of the patients in group A. In group B, there were significant differences in the levels of serum T, AMH, FAI, TG, LDLC, and HDLC, and the values of LH/FSH and HOMA-IR among the patients with amenorrhea, the patients with oligomenorrhea, and the patients with frequent menstruation. The abnormal changes of sex hormones levels and glucose and lipid metabolism indexes values of the patients with amenorrhea were significantly more obvious than those of the other patients. The levels of serum T, AMH, and FAI, and the values of LH/FSH and HOMA-IR of the patients with PCOS had increased gradually with the severity of their oligomenorrhea(all P＜0.05). Conclusion: There are differences in the serum sex hormones and glucose and lipid metabolism levels among the PCOS patients with different menstrual patterns. The abnormal sex hormones and glucose metabolism indexes increase of the patients with the severity of their oligomenorrhea, and which suggests that the levels of sex hormones and glucose metabolism of the PCOS patients with different menstrual patterns should be paid attention to in clinic, and the individual treatment for these patients should be carried out.
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