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Abstract To analyze the value of preoperative combined detection of human epididymal protein 4 (HE4), carbohydrate antigen 125 (CA125), osteopontin (OPN), and YKL-40 for evaluating the prognosis of endometrial carcinoma after operation. Methods: A total of 84 women with endometrial cancer who wanted elective surgery were selected in the study group from January 2017 to March 2018, and 84 healthy women who underwent physical examination were selected in the control group during the same time. The peripheral blood of the women in the study group before operation and of the women in the control group during the physical examination were collected to detect the serum HE4, CA125, OPN, and YKL-40 levels. The correlation between the serum HE4, CA125, OPN, and YKL-40 levels of the women in the study group and their clinical pathology and survival prognosis in 3 years after operation was analyze. The receiver operating characteristic (ROC) curve was used to analyze the value of the preoperative combined detection of the serum HE4, CA125, OPN, and YKL-40 levels of the women with endometrial cancer for evaluating their prognosis. Results: The serum levels of HE4, CA125, OPN and YKL-40 of the women in the study group after operation had increased significantly, and which of the women were significantly higher than those of the women in the control group. In the study group, there were significant differences in the levels of serum HE4, CA125, OPN, and YKL-40 among the women with different age, with different FIFO stage, with different tissue differentiation, with different lesion area, with different muscular infiltration, or with different lymphatic metastasis. The levels of serum HE4, CA125, OPN, and YKL-40 of the women with 3 years survival after surgery in the study group were significantly lower than those of the women with poor prognosis (P＜0.05). ROC curve shows that, the AUC of the levels of preoperative serum HE4 (84.33 pmol/L), CA125 (39.85 U/ml), OPN (37.55 ng/ml), and YKL-40 (614.91ng/ml) of the women in the study group for predicting their prognosis were 0.724, 0.588, 0.697, and 0.706, respectively, the sensitivity of which were 69.3%, 59.3%, 83.82%, and 69.6%, respectively, the specificity of which were 75.9%, 73.4%, 74.2%, 82.2%, respectively. The AUC, the sensitivity, and the specificity of the combined serum HE4, CA125, OPN, and YKL-40 levels of the women in the study group for predicting their prognosis were 0.914, 91.1%, and 94.2%, respectively. Conclusion: The increasing situation of preoperative serum HE4, CA125, OPN and YKL-40 levels are different in the women with different severity of endometrial cancer and in the women with different prognosis. The combined preoperative detections of serum HE4, CA125, OPN and YKL-40 levels can be used as important indicator to evaluating the prognosis of the women with endometrial cancer after surgery.
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