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| Effects of painless labor of pregnant women with hypertensive disorder complicating pregnancy on their serum inflammatory factors and hemodynamics |
| The Second People’s Hospital of Yibin，Yibin, Sichuan Province, 644000 |
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Abstract To investigate the effects of painless labor of pregnant women with hypertensive disorder complicating pregnancy (HDCP) on their serum inflammatory factors and hemodynamics. Methods: A total of 120 women with HDCP who had given birth in hospital were selected from January 2018 to March 2021, which included 60 cases with routine delivery in group A and 60 cases with painless delivery in group B. Another 60 healthy pregnant women who underwent painless labor were selected in group C during the same period. The levels of serum inflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and hemodynamic indicators, such as heart rate (HR), mean arterial pressure (MAP), and cardiac output (CO) of the women in the three groups before analgesia (T1), full opening of the uterine orifice (T2), fetal delivery (T3), and 24h of fetal delivery (T4) were detected. Results: The first stage of labor time, the second stage of labor time, the third stage of labor time, and the time the colostrum feeding of the women in group B and group A showed no significant different, but which of the women in group B and group A were all significantly lower than those of the women in group C. The 1min Apgar of newborns in group B and group A showed no significant different, but which of the newborns in group B and group A were all significantly higher than those of the newborns in group A (all P＜0.05). There was no significant difference in 5min Apgar score of the newborns among the three groups (P＞0.05). There were no significant differences in the levels of serum IL-6 and TNF-α of the women at T1 among the three groups (P＞0.05). The levels of serum IL-6 and TNF-α of the women in group B and group C at T2, T3 and T4 showed no significantly different, but which of the women in group B and group C were significantly lower than those of the women in group A (P＜0.05). There were no significant differences in the values of hemodynamic indexes, such as HR, MAP, CO, of the women at T1 and T4 among the three groups (P＞0.05), but the values of hemodynamic indexes of the women in group B and group C at T2 and T3 were significantly lower than those of the women in group A (P＜0.05). Conclusion: Painless delivery can effectively reduce the levels of serum inflammatory factors of pregnant women with HDCP during the perinatal period, and which has little effect on the maternal hemodynamics. Reasonable implementation of painless delivery for the pregnant women with HDCP is safe and effective.
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