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| Effects of epidural analgesia pump combined with intravenous analgesia during cesarean section on their inflammatory factors, coagulation function, and stress response |
| Guang'an People's Hospital, Guang'an, Sichuan Province, 638000 |
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Abstract To explore the effects of epidural analgesia pump combined with intravenous analgesia for treating women during cesarean section on their inflammatory factors, coagulation function, and stress response. Methods: 106 pregnant women who scheduled for cesarean section in the hospital were selected and were divided into two groups by random number table between September 2019 and September 2021. 53 women in group A were given patient controlled epidural analgesia, 53 women in group B were given patient controlled epidural analgesia combined with intravenous analgesia. The perioperative conditions, the postoperative pain score by visual analogue scale (VAS), the levels of serum C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and procalcitonin (PCT), the values of coagulation function indicators, such as prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and D-dimer (D-D), and the levels of stress response indicators, such as plasma cortisol (COR), angiotensin II (Ang II), epinephrine (E), and norepinephrine (NE) of the women were compared between the two groups. Results: The time (1.3±0.4d) of stay in bed of the women in group B was significantly shorter than that (1.6±0.4d) of the women in group A. The VAS score of the women in group B in postoperative 4 h (2.14±0.39 points), 8 h (2.56±0.51 points), 12 h (3.03±0.45 points), or 24 h (2.87±0.73 points), 48 h (2.34±0.35 points) of the women in group B was significantly was lower than that (2.68±0.42 points, 2.96±0.57 points, 3.32±0.43 points, 3.65±0.69 points, or 2.81±0.46 points) of the women in group A (all P＜0.05). After analgesia, the values of PT and APTT of the women in group B were significantly longer than those of the women in group A, and the levels of FIB, D-D, CRP, IL-6, TNF-α, PCT, COR, Ang II, E, and NE of the women in group B were significantly lower than those of the women in group A (P＜0.05). There was no significant difference in the complications rate (18.9% vs.11.3%) after analgesia of the women between the two groups (P＞0.05). Conclusion: Epidural analgesia pump combined with intravenous analgesia for treating the women has significant effective analgesia after cesarean section, which is better in relieving postoperative pain, improving the inflammatory response, inhibiting the hypercoagulability, and alleviating the stress response of the women than those of the epidural analgesia pump used only.
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