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| Influence of self-weight management of obese women with polycystic ovary syndrome on their pregnancy outcomes after in vitro fertilization-embryo transfer |
| Chengde Central Hospital, Chengde, Hebei Province, 067000 |
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Abstract To investigate the influence of self-weight management of obese women with polycystic ovary syndrome (PCOS) after in vitro fertilization-embryo transfer (IVF-ET) on their pregnancy outcomes. Methods：The convenience sampling method was used to select 108 obese women with PCOS who planned to receive IVF-ET in this study from January 2019 to December 2021. These women were divided into observation group (n=54) and control group (n=54) according to the random number table. The women in the control group were given conventional drug treatment, and the women in the observation group were given selfweight management based on treatment of the control group. The differences of body mass index (BMI), the time and dosage of gonadotropin hormone (Gn), the number of eggs obtained, the levels of adiponectin, leptin receptor, resistin, and leptin, and the rates of fertilization, optimal embryo, embryo implantation, and pregnancy of the women in the two groups were observed. The pregnancy outcomes of the women were compared between the two groups. Results: After treatment, The BMI value (24.8±1.5kg/m2), the duration of Gn used (10.7±1.3d), and the dosage of Gn used (1856.8±74.0IU) of the women in the observation group were significantly lower than those (27.6±1.8kg/m2, 13.1±1.6d, and 2483.6±78.4IU) of the women in the control group. The number of eggs obtained (16.35±2.51), and the levels of adiponectin (1.41±0.87ng/ml) and leptin receptor (3.40±1.14) of the women in the observation group were significantly higher than those (16.4±2.5, 0.97±0.62ng/ml, and 2.97±0.88) of the women in the control group. The levels of resistin (24.52±1.41ng/ml) and leptin (0.31±0.13mg/ml) of the women in the observation group were significantly lower than those (27.12±1.84 ng/ml and 0.43±0.15 mg/ml) of the women in the control group. The fertilization rate (85.2%), the optimal embryo rate (59.3%), the implanting rate (46.3%), and the pregnancy rate (48.2%) of the women in the observation group were significantly higher than those (72.2%, 44.4%, 24.1%, and 27.8%) of the women in the control group (all P＜0.05). Conclusion: Self-weight management of the obese women with PCOS is effective in reducing their BMI, and improving their treatment efficacy and pregnancy outcomes.
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