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| Influence difference of human menopausal gonadotropin and human chorionic gonadotropin for treating infertility patients on their ovulation induction effect, endometrial thickness, and pregnancy situation |
| Ningde City Hospital Affiliated to Ningde Normal University, Ningde, Fujian Province, 352100 |
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Abstract To analyze the ovulation induction effect of human menopausal gonadotropin (hMG) combined with human chorionic gonadotropin (HCG) for treating infertility patients, and to study its influence on the endometrial thickness and pregnancy status of these patients. Methods: 110 infertility patients were selected as the research objects from July 2018 to July 2021. According to the visit number, these patients were divided into observation group and control group (55 patients in each group). The patients in the control group were treated with hMG for 8 cycles, and the patients in the observation group were treated with hMG combined with HCG for 8 cycles. The therapeutic effect, follicle maturation rate, hMG dose, pregnancy status, maximum diameter of dominant follicle, and adverse reactions of the patients were compared between the two groups. Results: After treatment, the total effective rate (96.4%) of the patients in the observation group was significantly higher than that (83.6%) of the patients in the control group. The levels of serum progesterone, follicle-stimulating hormone, and testosterone of the patients in the observation group were significantly lower than those of the patients in the control group, but the levels of luteinizing hormone and estradiol of the patients in the observation group were significantly higher (all P＜0.05). With the prolong of treatment, the endometrial thickness of the patients in both groups had increased significantly, and which of the patients in the observation group was significantly higher than that of the patients in the control group (P＜0.05). The follicle maturation time (11.1±1.8 d) and the dose of hMG (6.8±1.2 vials) of the patients in the observation group were significantly lower than those (12.5±1.0 d and 10.0±1.0 vials) of the patients in the control group. The maximum diameter of dominant follicles of the patients in both groups had increased significantly after treatment, and which (18.6±2.4 mm) of the patients in the observation group was significantly higher than that (16.4±2.2 mm) of the patients in the control group (P＜0.05). The pregnancy rate (78.2%) of the patients in the observation group was significantly higher than that (60.0%) of the patients in the control group, the early pregnancy abortion rate (0) and multiple follicle development rate (0) of the patients in the observation group were significantly lower than those (9.1% and 7.3%) of the patients in the control group (all P＜0.05). Conclusion: HMG combined with HCG for treating the infertile patients has higher effect of ovulation induction, and which can improve the endometrial thickness and pregnancy condition significantly.
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