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| Effect of mifepristone combined with ethacridine for treating pregnant women with induced labor of scarred uterus during the second trimester of pregnancy and its influence on their cervical ripening |
| Yuncheng Central Hospital of Shanxi Province, Yuncheng, Shanxi Province, 044000 |
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Abstract To explore the intervention effect of mifepristone combined with ethacridine for treating pregnant women with induced labor of scarred uterus during the second trimester of pregnancy. Methods: The clinical data of 153 pregnant women with scarred uterus who had terminated the pregnancy by induced labor during the second trimester of pregnancy in the hospital from January 2017 to December 2021 were analyzed retrospectively. According to different method of labor induction, these women were divided into observation group (78 women with oral mifepristone combined with ethacridine amniocentesis for terminating their pregnancy) and control group (75 women with ethacridine amniocentesis for terminating their pregnancy). The cervical maturity situation, the perioperative indicators, the outcomes of labor induction, the rate of drug adverse reactions, and the incidence of postoperative complications of the women were compared between the two groups. Results: The Bishop scores of cervical maturity (7.01±1.18 points, 8.25±1.23 points, and 9.02±1.37 points) of the women in the observation group in 6, 12, and 18 h after treatment were significantly higher than those (6.59±1.02 points, 7.38±1.19 points, and 8.17±1.62 points) in the control group. The onset time of uterine contraction (20.12±2.15h), the labor induction time (4.12±0.68h), and the postpartum 2 h blood loss (126.27±20.13ml) of the women in the observation group were significantly lower than those (25.30±3.06h, 5.03±0.75h, and 139.48±19.54ml) of the women in the control group (all P＜0.05). There was no significant difference in the blood loss during labor induction of the women between the two groups (P＞0.05). The complete rate of labor induction (78.2%) of the women in the observation group was significantly higher than that (58.7%) of the women in the control group, and the rates of placental membranes residual (15.4%) and uterine curettage (20.5%) of the women in the observation group were significantly lower than those (29.3% and 36.0%) of the women in the control group (all P＜0.05). The success rate of labor induction (93.6% vs. 88.0%) of the women had no significant difference between the two groups (P＞0.05). The incidence of cervical edema and cervical lacerations (6.4%) of the women in the observation group was significantly lower than that (17.3%) of the women in the control group (P＜0.05). There was no significant difference in the incidence (10.3% vs. 6.7%) of adverse drug reaction, such as fever and uterine bleeding, of the women between the two groups (P＞0.05). Conclusion: Mifepristone combined with ethacridine for inducing labor of the women with scarred uterus during the second trimester of pregnancy can improve their cervical ripening, shorten the time of their uterine contractions and the time of labor induction, decrease their amount of postpartum bleeding and their incidences of uterine curettage and cervical lacerations, and which does not increase the adverse reaction of the women, with better safety.
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